Glenn M - Search Results

1

Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: structural recognition of STAT SH2 domains.

Gunning PT, Katt WP, Glenn M, Siddiquee K, Kim JS, Jove R, Sebti SM, Turkson J, Hamilton AD. Gunning PT, et al. Among authors: glenn m. Bioorg Med Chem Lett. 2007 Apr 1;17(7):1875-8. doi: 10.1016/j.bmcl.2007.01.077. Epub 2007 Jan 27. Bioorg Med Chem Lett. 2007. PMID: 17336521

2

Modifications of the GSK3beta substrate sequence to produce substrate-mimetic inhibitors of Akt as potential anti-cancer therapeutics.

Kayser KJ, Glenn MP, Sebti SM, Cheng JQ, Hamilton AD. Kayser KJ, et al. Among authors: glenn mp. Bioorg Med Chem Lett. 2007 Apr 1;17(7):2068-73. doi: 10.1016/j.bmcl.2007.01.004. Epub 2007 Jan 12. Bioorg Med Chem Lett. 2007. PMID: 17276059

3

Targeting protein-protein interactions: suppression of Stat3 dimerization with rationally designed small-molecule, nonpeptidic SH2 domain binders.

Gunning PT, Glenn MP, Siddiquee KA, Katt WP, Masson E, Sebti SM, Turkson J, Hamilton AD. Gunning PT, et al. Among authors: glenn mp. Chembiochem. 2008 Nov 24;9(17):2800-3. doi: 10.1002/cbic.200800291. Chembiochem. 2008. PMID: 19006150 Free PMC article. No abstract available.

4

Non-peptidic substrate-mimetic inhibitors of Akt as potential anti-cancer agents.

Kayser-Bricker KJ, Glenn MP, Lee SH, Sebti SM, Cheng JQ, Hamilton AD. Kayser-Bricker KJ, et al. Among authors: glenn mp. Bioorg Med Chem. 2009 Feb 15;17(4):1764-71. doi: 10.1016/j.bmc.2008.09.058. Epub 2008 Sep 27. Bioorg Med Chem. 2009. PMID: 19179081 Free PMC article.

5

Structurally simple, potent, Plasmodium selective farnesyltransferase inhibitors that arrest the growth of malaria parasites.

Glenn MP, Chang SY, Hornéy C, Rivas K, Yokoyama K, Pusateri EE, Fletcher S, Cummings CG, Buckner FS, Pendyala PR, Chakrabarti D, Sebti SM, Gelb M, Van Voorhis WC, Hamilton AD. Glenn MP, et al. J Med Chem. 2006 Sep 21;49(19):5710-27. doi: 10.1021/jm060081v. J Med Chem. 2006. PMID: 16970397 Free PMC article.

6

Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agents.

Fletcher S, Keaney EP, Cummings CG, Blaskovich MA, Hast MA, Glenn MP, Chang SY, Bucher CJ, Floyd RJ, Katt WP, Gelb MH, Van Voorhis WC, Beese LS, Sebti SM, Hamilton AD. Fletcher S, et al. Among authors: glenn mp. J Med Chem. 2010 Oct 14;53(19):6867-88. doi: 10.1021/jm1001748. J Med Chem. 2010. PMID: 20822181 Free PMC article.

7

Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity.

Turkson J, Kim JS, Zhang S, Yuan J, Huang M, Glenn M, Haura E, Sebti S, Hamilton AD, Jove R. Turkson J, et al. Among authors: glenn m. Mol Cancer Ther. 2004 Mar;3(3):261-9. Mol Cancer Ther. 2004. PMID: 15026546

8

Differential effects of Stat3 inhibition in sparse vs confluent normal and breast cancer cells.

Anagnostopoulou A, Vultur A, Arulanandam R, Cao J, Turkson J, Jove R, Kim JS, Glenn M, Hamilton AD, Raptis L. Anagnostopoulou A, et al. Among authors: glenn m. Cancer Lett. 2006 Oct 8;242(1):120-32. doi: 10.1016/j.canlet.2005.10.047. Epub 2005 Dec 27. Cancer Lett. 2006. PMID: 16377083

9

An oxazole-based small-molecule Stat3 inhibitor modulates Stat3 stability and processing and induces antitumor cell effects.

Siddiquee KA, Gunning PT, Glenn M, Katt WP, Zhang S, Schrock C, Sebti SM, Jove R, Hamilton AD, Turkson J. Siddiquee KA, et al. Among authors: glenn m. ACS Chem Biol. 2007 Dec 21;2(12):787-98. doi: 10.1021/cb7001973. ACS Chem Biol. 2007. PMID: 18154266

10

Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites.

Glenn MP, Chang SY, Hucke O, Verlinde CL, Rivas K, Hornéy C, Yokoyama K, Buckner FS, Pendyala PR, Chakrabarti D, Gelb M, Van Voorhis WC, Sebti SM, Hamilton AD. Glenn MP, et al. Angew Chem Int Ed Engl. 2005 Aug 5;44(31):4903-6. doi: 10.1002/anie.200500674. Angew Chem Int Ed Engl. 2005. PMID: 16007716 No abstract available.

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