Jove R - Search Results

1

Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: structural recognition of STAT SH2 domains.

Gunning PT, Katt WP, Glenn M, Siddiquee K, Kim JS, Jove R, Sebti SM, Turkson J, Hamilton AD. Gunning PT, et al. Among authors: jove r. Bioorg Med Chem Lett. 2007 Apr 1;17(7):1875-8. doi: 10.1016/j.bmcl.2007.01.077. Epub 2007 Jan 27. Bioorg Med Chem Lett. 2007. PMID: 17336521

2

Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity.

Turkson J, Kim JS, Zhang S, Yuan J, Huang M, Glenn M, Haura E, Sebti S, Hamilton AD, Jove R. Turkson J, et al. Among authors: jove r. Mol Cancer Ther. 2004 Mar;3(3):261-9. Mol Cancer Ther. 2004. PMID: 15026546

3

Differential effects of Stat3 inhibition in sparse vs confluent normal and breast cancer cells.

Anagnostopoulou A, Vultur A, Arulanandam R, Cao J, Turkson J, Jove R, Kim JS, Glenn M, Hamilton AD, Raptis L. Anagnostopoulou A, et al. Among authors: jove r. Cancer Lett. 2006 Oct 8;242(1):120-32. doi: 10.1016/j.canlet.2005.10.047. Epub 2005 Dec 27. Cancer Lett. 2006. PMID: 16377083

4

Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation.

Turkson J, Ryan D, Kim JS, Zhang Y, Chen Z, Haura E, Laudano A, Sebti S, Hamilton AD, Jove R. Turkson J, et al. Among authors: jove r. J Biol Chem. 2001 Nov 30;276(48):45443-55. doi: 10.1074/jbc.M107527200. Epub 2001 Sep 28. J Biol Chem. 2001. PMID: 11579100 Free article.

5

An oxazole-based small-molecule Stat3 inhibitor modulates Stat3 stability and processing and induces antitumor cell effects.

Siddiquee KA, Gunning PT, Glenn M, Katt WP, Zhang S, Schrock C, Sebti SM, Jove R, Hamilton AD, Turkson J. Siddiquee KA, et al. Among authors: jove r. ACS Chem Biol. 2007 Dec 21;2(12):787-98. doi: 10.1021/cb7001973. ACS Chem Biol. 2007. PMID: 18154266

6

Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity.

Siddiquee K, Zhang S, Guida WC, Blaskovich MA, Greedy B, Lawrence HR, Yip ML, Jove R, McLaughlin MM, Lawrence NJ, Sebti SM, Turkson J. Siddiquee K, et al. Among authors: jove r. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7391-6. doi: 10.1073/pnas.0609757104. Epub 2007 Apr 26. Proc Natl Acad Sci U S A. 2007. PMID: 17463090 Free PMC article.

7

Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity.

Sun J, Blaskovich MA, Jove R, Livingston SK, Coppola D, Sebti SM. Sun J, et al. Among authors: jove r. Oncogene. 2005 May 5;24(20):3236-45. doi: 10.1038/sj.onc.1208470. Oncogene. 2005. PMID: 15735720

8

STAT proteins: novel molecular targets for cancer drug discovery.

Turkson J, Jove R. Turkson J, et al. Among authors: jove r. Oncogene. 2000 Dec 27;19(56):6613-26. doi: 10.1038/sj.onc.1204086. Oncogene. 2000. PMID: 11426647 Review.

9

Cytoplasmic transport of Stat3 by receptor-mediated endocytosis.

Bild AH, Turkson J, Jove R. Bild AH, et al. Among authors: jove r. EMBO J. 2002 Jul 1;21(13):3255-63. doi: 10.1093/emboj/cdf351. EMBO J. 2002. PMID: 12093727 Free PMC article.

10

STAT3 activation by type I interferons is dependent on specific tyrosines located in the cytoplasmic domain of interferon receptor chain 2c. Activation of multiple STATS proceeds through the redundant usage of two tyrosine residues.

Velichko S, Wagner TC, Turkson J, Jove R, Croze E. Velichko S, et al. Among authors: jove r. J Biol Chem. 2002 Sep 20;277(38):35635-41. doi: 10.1074/jbc.M204578200. Epub 2002 Jun 24. J Biol Chem. 2002. PMID: 12105218 Free article.

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