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Potent, Plasmodium-selective farnesyltransferase inhibitors that arrest the growth of malaria parasites: structure-activity relationships of ethylenediamine-analogue scaffolds and homology model validation.
Fletcher S, Cummings CG, Rivas K, Katt WP, Hornéy C, Buckner FS, Chakrabarti D, Sebti SM, Gelb MH, Van Voorhis WC, Hamilton AD. Fletcher S, et al. Among authors: katt wp. J Med Chem. 2008 Sep 11;51(17):5176-97. doi: 10.1021/jm800113p. Epub 2008 Aug 8. J Med Chem. 2008. PMID: 18686940 Free PMC article.
Synthetic mimetics of protein secondary structure domains.
Ross NT, Katt WP, Hamilton AD. Ross NT, et al. Among authors: katt wp. Philos Trans A Math Phys Eng Sci. 2010 Mar 13;368(1914):989-1008. doi: 10.1098/rsta.2009.0210. Philos Trans A Math Phys Eng Sci. 2010. PMID: 20123744 Free PMC article. Review.
Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agents.
Fletcher S, Keaney EP, Cummings CG, Blaskovich MA, Hast MA, Glenn MP, Chang SY, Bucher CJ, Floyd RJ, Katt WP, Gelb MH, Van Voorhis WC, Beese LS, Sebti SM, Hamilton AD. Fletcher S, et al. Among authors: katt wp. J Med Chem. 2010 Oct 14;53(19):6867-88. doi: 10.1021/jm1001748. J Med Chem. 2010. PMID: 20822181 Free PMC article.
Design and evaluation of novel glutaminase inhibitors.
McDermott LA, Iyer P, Vernetti L, Rimer S, Sun J, Boby M, Yang T, Fioravanti M, O'Neill J, Wang L, Drakes D, Katt W, Huang Q, Cerione R. McDermott LA, et al. Bioorg Med Chem. 2016 Apr 15;24(8):1819-39. doi: 10.1016/j.bmc.2016.03.009. Epub 2016 Mar 7. Bioorg Med Chem. 2016. PMID: 26988803 Free PMC article.
GAC inhibitors with a 4-hydroxypiperidine spacer: Requirements for potency.
McDermott L, Koes D, Mohammed S, Iyer P, Boby M, Balasubramanian V, Geedy M, Katt W, Cerione R. McDermott L, et al. Bioorg Med Chem Lett. 2019 Oct 1;29(19):126632. doi: 10.1016/j.bmcl.2019.126632. Epub 2019 Aug 20. Bioorg Med Chem Lett. 2019. PMID: 31474484 Free PMC article.
40 results