Sebti SM - Search Results

1

Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: structural recognition of STAT SH2 domains.

Gunning PT, Katt WP, Glenn M, Siddiquee K, Kim JS, Jove R, Sebti SM, Turkson J, Hamilton AD. Gunning PT, et al. Among authors: sebti sm. Bioorg Med Chem Lett. 2007 Apr 1;17(7):1875-8. doi: 10.1016/j.bmcl.2007.01.077. Epub 2007 Jan 27. Bioorg Med Chem Lett. 2007. PMID: 17336521

2

Design, synthesis, and evaluation of potent and selective benzoyleneurea-based inhibitors of protein geranylgeranyltransferase-I.

Carrico D, Blaskovich MA, Bucher CJ, Sebti SM, Hamilton AD. Carrico D, et al. Among authors: sebti sm. Bioorg Med Chem. 2005 Feb 1;13(3):677-88. doi: 10.1016/j.bmc.2004.10.053. Bioorg Med Chem. 2005. PMID: 15653335

3

Modifications of the GSK3beta substrate sequence to produce substrate-mimetic inhibitors of Akt as potential anti-cancer therapeutics.

Kayser KJ, Glenn MP, Sebti SM, Cheng JQ, Hamilton AD. Kayser KJ, et al. Among authors: sebti sm. Bioorg Med Chem Lett. 2007 Apr 1;17(7):2068-73. doi: 10.1016/j.bmcl.2007.01.004. Epub 2007 Jan 12. Bioorg Med Chem Lett. 2007. PMID: 17276059

4

Potent, Plasmodium-selective farnesyltransferase inhibitors that arrest the growth of malaria parasites: structure-activity relationships of ethylenediamine-analogue scaffolds and homology model validation.

Fletcher S, Cummings CG, Rivas K, Katt WP, Hornéy C, Buckner FS, Chakrabarti D, Sebti SM, Gelb MH, Van Voorhis WC, Hamilton AD. Fletcher S, et al. Among authors: sebti sm. J Med Chem. 2008 Sep 11;51(17):5176-97. doi: 10.1021/jm800113p. Epub 2008 Aug 8. J Med Chem. 2008. PMID: 18686940 Free PMC article.

5

Targeting protein-protein interactions: suppression of Stat3 dimerization with rationally designed small-molecule, nonpeptidic SH2 domain binders.

Gunning PT, Glenn MP, Siddiquee KA, Katt WP, Masson E, Sebti SM, Turkson J, Hamilton AD. Gunning PT, et al. Among authors: sebti sm. Chembiochem. 2008 Nov 24;9(17):2800-3. doi: 10.1002/cbic.200800291. Chembiochem. 2008. PMID: 19006150 Free PMC article. No abstract available.

6

Non-peptidic substrate-mimetic inhibitors of Akt as potential anti-cancer agents.

Kayser-Bricker KJ, Glenn MP, Lee SH, Sebti SM, Cheng JQ, Hamilton AD. Kayser-Bricker KJ, et al. Among authors: sebti sm. Bioorg Med Chem. 2009 Feb 15;17(4):1764-71. doi: 10.1016/j.bmc.2008.09.058. Epub 2008 Sep 27. Bioorg Med Chem. 2009. PMID: 19179081 Free PMC article.

7

Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity.

Turkson J, Kim JS, Zhang S, Yuan J, Huang M, Glenn M, Haura E, Sebti S, Hamilton AD, Jove R. Turkson J, et al. Mol Cancer Ther. 2004 Mar;3(3):261-9. Mol Cancer Ther. 2004. PMID: 15026546

8

Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents.

Ohkanda J, Buckner FS, Lockman JW, Yokoyama K, Carrico D, Eastman R, de Luca-Fradley K, Davies W, Croft SL, Van Voorhis WC, Gelb MH, Sebti SM, Hamilton AD. Ohkanda J, et al. Among authors: sebti sm. J Med Chem. 2004 Jan 15;47(2):432-45. doi: 10.1021/jm030236o. J Med Chem. 2004. PMID: 14711313

9

In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability.

Carrico D, Ohkanda J, Kendrick H, Yokoyama K, Blaskovich MA, Bucher CJ, Buckner FS, Van Voorhis WC, Chakrabarti D, Croft SL, Gelb MH, Sebti SM, Hamilton AD. Carrico D, et al. Among authors: sebti sm. Bioorg Med Chem. 2004 Dec 15;12(24):6517-26. doi: 10.1016/j.bmc.2004.09.020. Bioorg Med Chem. 2004. PMID: 15556768

10

Structurally simple, potent, Plasmodium selective farnesyltransferase inhibitors that arrest the growth of malaria parasites.

Glenn MP, Chang SY, Hornéy C, Rivas K, Yokoyama K, Pusateri EE, Fletcher S, Cummings CG, Buckner FS, Pendyala PR, Chakrabarti D, Sebti SM, Gelb M, Van Voorhis WC, Hamilton AD. Glenn MP, et al. Among authors: sebti sm. J Med Chem. 2006 Sep 21;49(19):5710-27. doi: 10.1021/jm060081v. J Med Chem. 2006. PMID: 16970397 Free PMC article.

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