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Conditional inactivation of the E-cadherin gene in thyroid follicular cells affects gland development but does not impair junction formation.
Calì G, Zannini M, Rubini P, Tacchetti C, D'Andrea B, Affuso A, Wintermantel T, Boussadia O, Terracciano D, Silberschmidt D, Amendola E, De Felice M, Schütz G, Kemler R, Di Lauro R, Nitsch L. Calì G, et al. Among authors: di lauro r. Endocrinology. 2007 Jun;148(6):2737-46. doi: 10.1210/en.2006-1344. Epub 2007 Mar 8. Endocrinology. 2007. PMID: 17347311
A mouse model demonstrates a multigenic origin of congenital hypothyroidism.
Amendola E, De Luca P, Macchia PE, Terracciano D, Rosica A, Chiappetta G, Kimura S, Mansouri A, Affuso A, Arra C, Macchia V, Di Lauro R, De Felice M. Amendola E, et al. Among authors: di lauro r. Endocrinology. 2005 Dec;146(12):5038-47. doi: 10.1210/en.2005-0882. Epub 2005 Sep 8. Endocrinology. 2005. PMID: 16150900
A locus on mouse chromosome 2 is involved in susceptibility to congenital hypothyroidism and contains an essential gene expressed in thyroid.
Amendola E, Sanges R, Galvan A, Dathan N, Manenti G, Ferrandino G, Alvino FM, Di Palma T, Scarfò M, Zannini M, Dragani TA, De Felice M, Di Lauro R. Amendola E, et al. Among authors: di lauro r, di palma t. Endocrinology. 2010 Apr;151(4):1948-58. doi: 10.1210/en.2009-1240. Epub 2010 Feb 16. Endocrinology. 2010. PMID: 20160132
150 results