Race PR - Search Results

1

Kinetic and structural characterisation of Escherichia coli nitroreductase mutants showing improved efficacy for the prodrug substrate CB1954.

Race PR, Lovering AL, White SA, Grove JI, Searle PF, Wrighton CW, Hyde EI. Race PR, et al. J Mol Biol. 2007 Apr 27;368(2):481-92. doi: 10.1016/j.jmb.2007.02.012. Epub 2007 Feb 11. J Mol Biol. 2007. PMID: 17350040

2

Generation of Escherichia coli nitroreductase mutants conferring improved cell sensitization to the prodrug CB1954.

Grove JI, Lovering AL, Guise C, Race PR, Wrighton CJ, White SA, Hyde EI, Searle PF. Grove JI, et al. Among authors: race pr. Cancer Res. 2003 Sep 1;63(17):5532-7. Cancer Res. 2003. PMID: 14500391

3

Nitroreductase: a prodrug-activating enzyme for cancer gene therapy.

Searle PF, Chen MJ, Hu L, Race PR, Lovering AL, Grove JI, Guise C, Jaberipour M, James ND, Mautner V, Young LS, Kerr DJ, Mountain A, White SA, Hyde EI. Searle PF, et al. Among authors: race pr. Clin Exp Pharmacol Physiol. 2004 Nov;31(11):811-6. doi: 10.1111/j.1440-1681.2004.04085.x. Clin Exp Pharmacol Physiol. 2004. PMID: 15566399 Review.

4

Structural and mechanistic studies of Escherichia coli nitroreductase with the antibiotic nitrofurazone. Reversed binding orientations in different redox states of the enzyme.

Race PR, Lovering AL, Green RM, Ossor A, White SA, Searle PF, Wrighton CJ, Hyde EI. Race PR, et al. J Biol Chem. 2005 Apr 8;280(14):13256-64. doi: 10.1074/jbc.M409652200. Epub 2005 Jan 31. J Biol Chem. 2005. PMID: 15684426 Free article.

5

Nitroaryl phosphoramides as novel prodrugs for E. coli nitroreductase activation in enzyme prodrug therapy.

Hu L, Yu C, Jiang Y, Han J, Li Z, Browne P, Race PR, Knox RJ, Searle PF, Hyde EI. Hu L, et al. Among authors: race pr. J Med Chem. 2003 Nov 6;46(23):4818-21. doi: 10.1021/jm034133h. J Med Chem. 2003. PMID: 14584930

6

Fine Tuning of Antibiotic Activity by a Tailoring Hydroxylase in a Trans-AT Polyketide Synthase Pathway.

Mohammad HH, Connolly JA, Song Z, Hothersall J, Race PR, Willis CL, Simpson TJ, Winn PJ, Thomas CM. Mohammad HH, et al. Among authors: race pr. Chembiochem. 2018 Apr 16;19(8):836-841. doi: 10.1002/cbic.201800036. Epub 2018 Mar 13. Chembiochem. 2018. PMID: 29363252

7

A Priming Cassette Generates Hydroxylated Acyl Starter Units in Mupirocin and Thiomarinol Biosynthesis.

Walker PD, Rowe MT, Winter AJ, Weir ANM, Akter N, Wang L, Race PR, Williams C, Song Z, Simpson TJ, Willis CL, Crump MP. Walker PD, et al. Among authors: race pr. ACS Chem Biol. 2020 Feb 21;15(2):494-503. doi: 10.1021/acschembio.9b00969. Epub 2020 Feb 6. ACS Chem Biol. 2020. PMID: 31977176

8

The Assembly Line Enzymology of Polyketide Biosynthesis.

Till M, Race PR. Till M, et al. Among authors: race pr. Methods Mol Biol. 2016;1401:31-49. doi: 10.1007/978-1-4939-3375-4_2. Methods Mol Biol. 2016. PMID: 26831699

9

Insertion of the enteropathogenic Escherichia coli Tir virulence protein into membranes in vitro.

Race PR, Lakey JH, Banfield MJ. Race PR, et al. J Biol Chem. 2006 Mar 24;281(12):7842-9. doi: 10.1074/jbc.M513532200. Epub 2006 Jan 24. J Biol Chem. 2006. PMID: 16436373 Free article.

10

Crystal structure of Streptococcus pyogenes sortase A: implications for sortase mechanism.

Race PR, Bentley ML, Melvin JA, Crow A, Hughes RK, Smith WD, Sessions RB, Kehoe MA, McCafferty DG, Banfield MJ. Race PR, et al. J Biol Chem. 2009 Mar 13;284(11):6924-33. doi: 10.1074/jbc.M805406200. Epub 2009 Jan 6. J Biol Chem. 2009. PMID: 19129180 Free PMC article.

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