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Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess.
Barbour LA, Mizanoor Rahman S, Gurevich I, Leitner JW, Fischer SJ, Roper MD, Knotts TA, Vo Y, McCurdy CE, Yakar S, Leroith D, Kahn CR, Cantley LC, Friedman JE, Draznin B. Barbour LA, et al. Among authors: mccurdy ce. J Biol Chem. 2005 Nov 11;280(45):37489-94. doi: 10.1074/jbc.M506967200. Epub 2005 Sep 8. J Biol Chem. 2005. PMID: 16166093 Free article.
Skeletal muscle-specific deletion of lipoprotein lipase enhances insulin signaling in skeletal muscle but causes insulin resistance in liver and other tissues.
Wang H, Knaub LA, Jensen DR, Young Jung D, Hong EG, Ko HJ, Coates AM, Goldberg IJ, de la Houssaye BA, Janssen RC, McCurdy CE, Rahman SM, Soo Choi C, Shulman GI, Kim JK, Friedman JE, Eckel RH. Wang H, et al. Among authors: mccurdy ce. Diabetes. 2009 Jan;58(1):116-24. doi: 10.2337/db07-1839. Epub 2008 Oct 24. Diabetes. 2009. PMID: 18952837 Free PMC article.
Maternal Obesity and Western-Style Diet Impair Fetal and Juvenile Offspring Skeletal Muscle Insulin-Stimulated Glucose Transport in Nonhuman Primates.
Campodonico-Burnett W, Hetrick B, Wesolowski SR, Schenk S, Takahashi DL, Dean TA, Sullivan EL, Kievit P, Gannon M, Aagaard K, Friedman JE, McCurdy CE. Campodonico-Burnett W, et al. Among authors: mccurdy ce. Diabetes. 2020 Jul;69(7):1389-1400. doi: 10.2337/db19-1218. Epub 2020 Apr 30. Diabetes. 2020. PMID: 32354857 Free PMC article.
51 results