Nacro K - Search Results

1

Synthesis and topoisomerase poisoning activity of A-ring and E-ring substituted luotonin A derivatives.

Nacro K, Zha CC, Guzzo PR, Jason Herr R, Peace D, Friedrich TD. Nacro K, et al. Bioorg Med Chem. 2007 Jun 15;15(12):4237-46. doi: 10.1016/j.bmc.2007.03.067. Epub 2007 Mar 25. Bioorg Med Chem. 2007. PMID: 17418582

2

Epiminocyclohepta[b]indole analogs as 5-HT6 antagonists.

Henderson AJ, Guzzo PR, Ghosh A, Kaur J, Koo JM, Nacro K, Panduga S, Pathak R, Shimpukade B, Tan V, Xiang K, Wierschke JD, Isherwood ML. Henderson AJ, et al. Among authors: nacro k. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1494-8. doi: 10.1016/j.bmcl.2012.01.022. Epub 2012 Jan 14. Bioorg Med Chem Lett. 2012. PMID: 22290076

3

Design and synthesis of 4-heteroaryl 1,2,3,4-tetrahydroisoquinolines as triple reuptake inhibitors.

Liu S, Zha C, Nacro K, Hu M, Cui W, Yang YL, Bhatt U, Sambandam A, Isherwood M, Yet L, Herr MT, Ebeltoft S, Hassler C, Fleming L, Pechulis AD, Payen-Fornicola A, Holman N, Milanowski D, Cotterill I, Mozhaev V, Khmelnitsky Y, Guzzo PR, Sargent BJ, Molino BF, Olson R, King D, Lelas S, Li YW, Johnson K, Molski T, Orie A, Ng A, Haskell R, Clarke W, Bertekap R, O'Connell J, Lodge N, Sinz M, Adams S, Zaczek R, Macor JE. Liu S, et al. Among authors: nacro k. ACS Med Chem Lett. 2014 May 13;5(7):760-5. doi: 10.1021/ml500053b. eCollection 2014 Jul 10. ACS Med Chem Lett. 2014. PMID: 25050161 Free PMC article.

4

Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening.

Enyedy IJ, Ling Y, Nacro K, Tomita Y, Wu X, Cao Y, Guo R, Li B, Zhu X, Huang Y, Long YQ, Roller PP, Yang D, Wang S. Enyedy IJ, et al. Among authors: nacro k. J Med Chem. 2001 Dec 6;44(25):4313-24. doi: 10.1021/jm010016f. J Med Chem. 2001. PMID: 11728179

5

Stepwise Evolution of Fragment Hits against MAPK Interacting Kinases 1 and 2.

Kwiatkowski J, Liu B, Pang S, Ahmad NHB, Wang G, Poulsen A, Yang H, Poh YR, Tee DHY, Ong E, Retna P, Dinie N, Kwek P, Wee JLK, Manoharan V, Low CB, Seah PG, Pendharkar V, Sangthongpitag K, Joy J, Baburajendran N, Jansson AE, Nacro K, Hill J, Keller TH, Hung AW. Kwiatkowski J, et al. Among authors: nacro k. J Med Chem. 2020 Jan 23;63(2):621-637. doi: 10.1021/acs.jmedchem.9b01582. Epub 2020 Jan 7. J Med Chem. 2020. PMID: 31910010

6

Conformationally constrained analogues of diacylglycerol (DAG). 16. How much structural complexity is necessary for recognition and high binding affinity to protein kinase C?

Nacro K, Bienfait B, Lee J, Han KC, Kang JH, Benzaria S, Lewin NE, Bhattacharyya DK, Blumberg PM, Marquez VE. Nacro K, et al. J Med Chem. 2000 Mar 9;43(5):921-44. doi: 10.1021/jm9904607. J Med Chem. 2000. PMID: 10715158

7

Diacylglycerols with lipophilically equivalent branched acyl chains display high affinity for protein kinase C (PK-C). A direct measure of the effect of constraining the glycerol backbone in DAG lactones.

Nacro K, Bienfait B, Lewin NE, Blumberg PM, Marquez VE. Nacro K, et al. Bioorg Med Chem Lett. 2000 Apr 3;10(7):653-5. doi: 10.1016/s0960-894x(00)00070-6. Bioorg Med Chem Lett. 2000. PMID: 10762046

8

Update on the Development of MNK Inhibitors as Therapeutic Agents.

Xu W, Kannan S, Verma CS, Nacro K. Xu W, et al. Among authors: nacro k. J Med Chem. 2022 Jan 27;65(2):983-1007. doi: 10.1021/acs.jmedchem.1c00368. Epub 2021 Sep 17. J Med Chem. 2022. PMID: 34533957 Review.

9

Conformationally constrained analogues of diacylglycerol (DAG). 15. The indispensable role of the sn-1 and sn-2 carbonyls in the binding of DAG-lactones to protein kinase C (PK-C).

Benzaria S, Bienfait B, Nacro K, Wang S, Lewin NE, Beheshti M, Blumberg PM, Marquez VE. Benzaria S, et al. Among authors: nacro k. Bioorg Med Chem Lett. 1998 Dec 1;8(23):3403-8. doi: 10.1016/s0960-894x(98)00614-3. Bioorg Med Chem Lett. 1998. PMID: 9873742

10

Probing the binding mechanism of Mnk inhibitors by docking and molecular dynamics simulations.

Kannan S, Poulsen A, Yang HY, Ho M, Ang SH, Eldwin TS, Jeyaraj DA, Chennamaneni LR, Liu B, Hill J, Verma CS, Nacro K. Kannan S, et al. Among authors: nacro k. Biochemistry. 2015 Jan 13;54(1):32-46. doi: 10.1021/bi501261j. Epub 2014 Dec 5. Biochemistry. 2015. PMID: 25431995

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