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1,159 results

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Page 1
Identification and optimization of novel 1,3,4-oxadiazole EP1 receptor antagonists.
Hall A, Brown SH, Chowdhury A, Giblin GM, Gibson M, Healy MP, Livermore DG, Wilson RJ, Naylor A, Rawlings DA, Roman S, Ward E, Willay C. Hall A, et al. Among authors: roman s. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4450-5. doi: 10.1016/j.bmcl.2007.06.014. Epub 2007 Jun 8. Bioorg Med Chem Lett. 2007. PMID: 17574410
Discovery and structure-activity relationships of a series of pyroglutamic acid amide antagonists of the P2X7 receptor.
Abdi MH, Beswick PJ, Billinton A, Chambers LJ, Charlton A, Collins SD, Collis KL, Dean DK, Fonfria E, Gleave RJ, Lejeune CL, Livermore DG, Medhurst SJ, Michel AD, Moses AP, Page L, Patel S, Roman SA, Senger S, Slingsby B, Steadman JG, Stevens AJ, Walter DS. Abdi MH, et al. Among authors: roman sa. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5080-4. doi: 10.1016/j.bmcl.2010.07.033. Epub 2010 Jul 14. Bioorg Med Chem Lett. 2010. PMID: 20673717
Identification of novel glycine sulfonamide antagonists for the EP1 receptor.
McKeown SC, Hall A, Blunt R, Brown SH, Chessell IP, Chowdhury A, Giblin GM, Healy MP, Johnson MR, Lorthioir O, Michel AD, Naylor A, Lewell X, Roman S, Watson SP, Winchester WJ, Wilson RJ. McKeown SC, et al. Among authors: roman s. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1750-4. doi: 10.1016/j.bmcl.2006.12.060. Epub 2006 Dec 22. Bioorg Med Chem Lett. 2007. PMID: 17236765
Synthesis and structure-activity relationships of a series of (1H-pyrazol-4-yl)acetamide antagonists of the P2X7 receptor.
Chambers LJ, Stevens AJ, Moses AP, Michel AD, Walter DS, Davies DJ, Livermore DG, Fonfria E, Demont EH, Vimal M, Theobald PJ, Beswick PJ, Gleave RJ, Roman SA, Senger S. Chambers LJ, et al. Among authors: roman sa. Bioorg Med Chem Lett. 2010 May 15;20(10):3161-4. doi: 10.1016/j.bmcl.2010.03.096. Epub 2010 Mar 30. Bioorg Med Chem Lett. 2010. PMID: 20399651
Structure-activity relationships and in vivo activity of (1H-pyrazol-4-yl)acetamide antagonists of the P2X(7) receptor.
Beswick PJ, Billinton A, Chambers LJ, Dean DK, Fonfria E, Gleave RJ, Medhurst SJ, Michel AD, Moses AP, Patel S, Roman SA, Roomans S, Senger S, Stevens AJ, Walter DS. Beswick PJ, et al. Among authors: roman sa. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4653-6. doi: 10.1016/j.bmcl.2010.05.107. Epub 2010 Jun 8. Bioorg Med Chem Lett. 2010. PMID: 20579878
Identification of 2-oxo-N-(phenylmethyl)-4-imidazolidinecarboxamide antagonists of the P2X(7) receptor.
Abberley L, Bebius A, Beswick PJ, Billinton A, Collis KL, Dean DK, Fonfria E, Gleave RJ, Medhurst SJ, Michel AD, Moses AP, Patel S, Roman SA, Scoccitti T, Smith B, Steadman JG, Walter DS. Abberley L, et al. Among authors: roman sa. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6370-4. doi: 10.1016/j.bmcl.2010.09.101. Epub 2010 Sep 22. Bioorg Med Chem Lett. 2010. PMID: 20934331
Mechanism of action of species-selective P2X(7) receptor antagonists.
Michel AD, Ng SW, Roman S, Clay WC, Dean DK, Walter DS. Michel AD, et al. Among authors: roman s. Br J Pharmacol. 2009 Apr;156(8):1312-25. doi: 10.1111/j.1476-5381.2009.00135.x. Epub 2009 Mar 20. Br J Pharmacol. 2009. PMID: 19309360 Free PMC article.
1,159 results