Mertz T - Search Results

1

Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors.

Pfefferkorn JA, Song Y, Sun KL, Miller SR, Trivedi BK, Choi C, Sorenson RJ, Bratton LD, Unangst PC, Larsen SD, Poel TJ, Cheng XM, Lee C, Erasga N, Auerbach B, Askew V, Dillon L, Hanselman JC, Lin Z, Lu G, Robertson A, Olsen K, Mertz T, Sekerke C, Pavlovsky A, Harris MS, Bainbridge G, Caspers N, Chen H, Eberstadt M. Pfefferkorn JA, et al. Among authors: mertz t. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4538-44. doi: 10.1016/j.bmcl.2007.05.096. Epub 2007 Jun 6. Bioorg Med Chem Lett. 2007. PMID: 17574412

2

Substituted oxazolidinones as novel NPC1L1 ligands for the inhibition of cholesterol absorption.

Pfefferkorn JA, Larsen SD, Van Huis C, Sorenson R, Barton T, Winters T, Auerbach B, Wu C, Wolfram TJ, Cai H, Welch K, Esmaiel N, Davis J, Bousley R, Olsen K, Mueller SB, Mertz T. Pfefferkorn JA, et al. Among authors: mertz t. Bioorg Med Chem Lett. 2008 Jan 15;18(2):546-53. doi: 10.1016/j.bmcl.2007.11.083. Epub 2007 Nov 28. Bioorg Med Chem Lett. 2008. PMID: 18063367

3

Design, synthesis, and biological activity of potent and selective inhibitors of blood coagulation factor Xa.

Willardsen JA, Dudley DA, Cody WL, Chi L, McClanahan TB, Mertz TE, Potoczak RE, Narasimhan LS, Holland DR, Rapundalo ST, Edmunds JJ. Willardsen JA, et al. Among authors: mertz te. J Med Chem. 2004 Jul 29;47(16):4089-99. doi: 10.1021/jm0497491. J Med Chem. 2004. PMID: 15267248

4

Rational design, synthesis, and biological activity of benzoxazinones as novel factor Xa inhibitors.

Dudley DA, Bunker AM, Chi L, Cody WL, Holland DR, Ignasiak DP, Janiczek-Dolphin N, McClanahan TB, Mertz TE, Narasimhan LS, Rapundalo ST, Trautschold JA, Van Huis CA, Edmunds JJ. Dudley DA, et al. Among authors: mertz te. J Med Chem. 2000 Nov 2;43(22):4063-70. doi: 10.1021/jm000074l. J Med Chem. 2000. PMID: 11063603

5

Synthesis and antiarrhythmic activity of alpha-[(diarylmethoxy)methyl]-1-piperidineethanols.

Hoefle ML, Blouin LT, Fleming RW, Hastings S, Hinkley JM, Mertz TE, Steffe TJ, Stratton CS, Werbel LM. Hoefle ML, et al. Among authors: mertz te. J Med Chem. 1991 Jan;34(1):7-12. doi: 10.1021/jm00105a002. J Med Chem. 1991. PMID: 1992154

6

Synthesis and antiarrhythmic activity of cis-2,6-dimethyl-alpha,alpha-diaryl-1-piperidinebutanols.

Hoefle ML, Blouin LT, Fleming RW, Hastings S, Hinkley JM, Mertz TE, Steffe TJ, Stratton CS. Hoefle ML, et al. Among authors: mertz te. J Med Chem. 1991 Jan;34(1):12-9. doi: 10.1021/jm00105a003. J Med Chem. 1991. PMID: 1992110

7

Assessment of ex vivo pharmacodynamic markers during inhibition of thrombosis by CI-1031 (ZK-807834), a novel direct factor Xa inhibitor.

Chi L, Pen YW, Potoczak R, Gibson G, Hicks G, Mertz TE, Janiczek N, Juneau PL, Gallagher K, Leadley R. Chi L, et al. Pharmacology. 2002 Feb;64(2):76-83. doi: 10.1159/000056154. Pharmacology. 2002. PMID: 11803247

8

The antithrombotic effects of CI-1031 (ZK-807834) and enoxaparin in a canine electrolytic injury model of arterial and venous thrombosis.

McClanahan TB, Hicks GW, Morrison AL, Peng YW, Janiczek-Dolphin N, Mertz TE, Sullivan ME, Morser J, Juneau PL, Leadley R. McClanahan TB, et al. Among authors: mertz te. Eur J Pharmacol. 2001 Dec 7;432(2-3):187-94. doi: 10.1016/s0014-2999(01)01090-1. Eur J Pharmacol. 2001. PMID: 11740955

9

In vitro and in vivo antithrombotic activity of PD-198961, a novel synthetic factor Xa inhibitor.

Chi L, Peng YW, Gibson G, Hicks G, Mertz TE, Rapundalo S, Janiczek N, Edmunds JJ, Leadley R. Chi L, et al. J Cardiovasc Pharmacol. 2004 Oct;44(4):493-500. doi: 10.1097/01.fjc.0000141475.14007.ab. J Cardiovasc Pharmacol. 2004. PMID: 15454859

10

The antithrombotic effects of CI-1028, an orally bioavailable direct thrombin inhibitor, in a canine model of venous and arterial thrombosis.

McClanahan TB, Hicks GW, Ignasiak DP, Bousley R, Mertz TE, Juneau P, Janiczek-Dolphin N, Kim IC, Gallagher KP. McClanahan TB, et al. Among authors: mertz te. J Thromb Thrombolysis. 2000 Dec;10(3):277-84. doi: 10.1023/a:1026555510258. J Thromb Thrombolysis. 2000. PMID: 11122549

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