Sutcliffe OB - Search Results

1

Dual aromatase-steroid sulfatase inhibitors.

Woo LW, Bubert C, Sutcliffe OB, Smith A, Chander SK, Mahon MF, Purohit A, Reed MJ, Potter BV. Woo LW, et al. Among authors: sutcliffe ob. J Med Chem. 2007 Jul 26;50(15):3540-60. doi: 10.1021/jm061462b. Epub 2007 Jun 20. J Med Chem. 2007. PMID: 17580845

2

First dual aromatase-steroid sulfatase inhibitors.

Woo LW, Sutcliffe OB, Bubert C, Grasso A, Chander SK, Purohit A, Reed MJ, Potter BV. Woo LW, et al. Among authors: sutcliffe ob. J Med Chem. 2003 Jul 17;46(15):3193-6. doi: 10.1021/jm034033b. J Med Chem. 2003. PMID: 12852749

3

First crystal structures of human carbonic anhydrase II in complex with dual aromatase-steroid sulfatase inhibitors.

Lloyd MD, Thiyagarajan N, Ho YT, Woo LW, Sutcliffe OB, Purohit A, Reed MJ, Acharya KR, Potter BV. Lloyd MD, et al. Among authors: sutcliffe ob. Biochemistry. 2005 May 10;44(18):6858-66. doi: 10.1021/bi047692e. Biochemistry. 2005. PMID: 15865431

4

Synthesis of aromatase inhibitors and dual aromatase steroid sulfatase inhibitors by linking an arylsulfamate motif to 4-(4H-1,2,4-triazol-4-ylamino)benzonitrile: SAR, crystal structures, in vitro and in vivo activities.

Bubert C, Woo LW, Sutcliffe OB, Mahon MF, Chander SK, Purohit A, Reed MJ, Potter BV. Bubert C, et al. Among authors: sutcliffe ob. ChemMedChem. 2008 Nov;3(11):1708-30. doi: 10.1002/cmdc.200800164. ChemMedChem. 2008. PMID: 18816537

5

A new therapeutic strategy against hormone-dependent breast cancer: the preclinical development of a dual aromatase and sulfatase inhibitor.

Foster PA, Chander SK, Newman SP, Woo LW, Sutcliffe OB, Bubert C, Zhou D, Chen S, Potter BV, Reed MJ, Purohit A. Foster PA, et al. Among authors: sutcliffe ob. Clin Cancer Res. 2008 Oct 15;14(20):6469-77. doi: 10.1158/1078-0432.CCR-08-1027. Clin Cancer Res. 2008. PMID: 18927286 Free article.

6

Structure-activity relationship for the first-in-class clinical steroid sulfatase inhibitor Irosustat (STX64, BN83495).

Woo LW, Ganeshapillai D, Thomas MP, Sutcliffe OB, Malini B, Mahon MF, Purohit A, Potter BV. Woo LW, et al. Among authors: sutcliffe ob. ChemMedChem. 2011 Nov 4;6(11):2019-34. doi: 10.1002/cmdc.201100288. Epub 2011 Aug 25. ChemMedChem. 2011. PMID: 21990014 Free PMC article.

7

Triphenylbutanamines: kinesin spindle protein inhibitors with in vivo antitumor activity.

Wang F, Good JA, Rath O, Kaan HY, Sutcliffe OB, Mackay SP, Kozielski F. Wang F, et al. Among authors: sutcliffe ob. J Med Chem. 2012 Feb 23;55(4):1511-25. doi: 10.1021/jm201195m. Epub 2012 Feb 13. J Med Chem. 2012. PMID: 22248262 Free PMC article.

8

Doing the methylene shuffle--further insights into the inhibition of mitotic kinesin Eg5 with S-trityl L-cysteine.

Abualhasan MN, Good JA, Wittayanarakul K, Anthony NG, Berretta G, Rath O, Kozielski F, Sutcliffe OB, Mackay SP. Abualhasan MN, et al. Among authors: sutcliffe ob. Eur J Med Chem. 2012 Aug;54:483-98. doi: 10.1016/j.ejmech.2012.05.034. Epub 2012 Jun 7. Eur J Med Chem. 2012. PMID: 22749640

9

Inhibitory Kappa B Kinase α (IKKα) Inhibitors That Recapitulate Their Selectivity in Cells against Isoform-Related Biomarkers.

Anthony NG, Baiget J, Berretta G, Boyd M, Breen D, Edwards J, Gamble C, Gray AI, Harvey AL, Hatziieremia S, Ho KH, Huggan JK, Lang S, Llona-Minguez S, Luo JL, McIntosh K, Paul A, Plevin RJ, Robertson MN, Scott R, Suckling CJ, Sutcliffe OB, Young LC, Mackay SP. Anthony NG, et al. Among authors: sutcliffe ob. J Med Chem. 2017 Aug 24;60(16):7043-7066. doi: 10.1021/acs.jmedchem.7b00484. Epub 2017 Aug 15. J Med Chem. 2017. PMID: 28737909 Free PMC article.

10

Microwave synthesis of cucurbit[n]urils.

Wheate NJ, Patel N, Sutcliffe OB. Wheate NJ, et al. Among authors: sutcliffe ob. Future Med Chem. 2010 Feb;2(2):231-6. doi: 10.4155/fmc.09.118. Future Med Chem. 2010. PMID: 21426190

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