Lesley SA - Search Results

1

Secreted PCSK9 promotes LDL receptor degradation independently of proteolytic activity.

Li J, Tumanut C, Gavigan JA, Huang WJ, Hampton EN, Tumanut R, Suen KF, Trauger JW, Spraggon G, Lesley SA, Liau G, Yowe D, Harris JL. Li J, et al. Among authors: lesley sa. Biochem J. 2007 Sep 1;406(2):203-7. doi: 10.1042/BJ20070664. Biochem J. 2007. PMID: 17608623 Free PMC article.

2

The self-inhibited structure of full-length PCSK9 at 1.9 A reveals structural homology with resistin within the C-terminal domain.

Hampton EN, Knuth MW, Li J, Harris JL, Lesley SA, Spraggon G. Hampton EN, et al. Among authors: lesley sa. Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14604-9. doi: 10.1073/pnas.0703402104. Epub 2007 Sep 5. Proc Natl Acad Sci U S A. 2007. PMID: 17804797 Free PMC article.

3

Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain.

Lee CC, Jia Y, Li N, Sun X, Ng K, Ambing E, Gao MY, Hua S, Chen C, Kim S, Michellys PY, Lesley SA, Harris JL, Spraggon G. Lee CC, et al. Among authors: lesley sa. Biochem J. 2010 Sep 15;430(3):425-37. doi: 10.1042/BJ20100609. Biochem J. 2010. PMID: 20632993

4

Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations.

Spraggon G, Hornsby M, Shipway A, Tully DC, Bursulaya B, Danahay H, Harris JL, Lesley SA. Spraggon G, et al. Among authors: lesley sa. Protein Sci. 2009 May;18(5):1081-94. doi: 10.1002/pro.118. Protein Sci. 2009. PMID: 19388054 Free PMC article.

5

Computational analysis of crystallization trials.

Spraggon G, Lesley SA, Kreusch A, Priestle JP. Spraggon G, et al. Among authors: lesley sa. Acta Crystallogr D Biol Crystallogr. 2002 Nov;58(Pt 11):1915-23. doi: 10.1107/s0907444902016840. Epub 2002 Oct 21. Acta Crystallogr D Biol Crystallogr. 2002. PMID: 12393922

6

The Thermotoga maritima Trk potassium transporter--from frameshift to function.

Johnson HA, Hampton E, Lesley SA. Johnson HA, et al. Among authors: lesley sa. J Bacteriol. 2009 Apr;191(7):2276-84. doi: 10.1128/JB.01367-08. Epub 2009 Jan 23. J Bacteriol. 2009. PMID: 19168617 Free PMC article.

7

Structural insights into enzyme regulation for inositol 1,4,5-trisphosphate 3-kinase B.

Chamberlain PP, Sandberg ML, Sauer K, Cooke MP, Lesley SA, Spraggon G. Chamberlain PP, et al. Among authors: lesley sa. Biochemistry. 2005 Nov 8;44(44):14486-93. doi: 10.1021/bi051256q. Biochemistry. 2005. PMID: 16262249

8

On the use of DXMS to produce more crystallizable proteins: structures of the T. maritima proteins TM0160 and TM1171.

Spraggon G, Pantazatos D, Klock HE, Wilson IA, Woods VL Jr, Lesley SA. Spraggon G, et al. Among authors: lesley sa. Protein Sci. 2004 Dec;13(12):3187-99. doi: 10.1110/ps.04939904. Protein Sci. 2004. PMID: 15557262 Free PMC article.

9

Integration of inositol phosphate signaling pathways via human ITPK1.

Chamberlain PP, Qian X, Stiles AR, Cho J, Jones DH, Lesley SA, Grabau EA, Shears SB, Spraggon G. Chamberlain PP, et al. Among authors: lesley sa. J Biol Chem. 2007 Sep 21;282(38):28117-25. doi: 10.1074/jbc.M703121200. Epub 2007 Jul 6. J Biol Chem. 2007. PMID: 17616525 Free PMC article.

10

Structure analysis of peptide deformylases from Streptococcus pneumoniae, Staphylococcus aureus, Thermotoga maritima and Pseudomonas aeruginosa: snapshots of the oxygen sensitivity of peptide deformylase.

Kreusch A, Spraggon G, Lee CC, Klock H, McMullan D, Ng K, Shin T, Vincent J, Warner I, Ericson C, Lesley SA. Kreusch A, et al. Among authors: lesley sa. J Mol Biol. 2003 Jul 4;330(2):309-21. doi: 10.1016/s0022-2836(03)00596-5. J Mol Biol. 2003. PMID: 12823970

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