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TNF-induced structural joint damage is mediated by IL-1.
Zwerina J, Redlich K, Polzer K, Joosten L, Krönke G, Distler J, Hess A, Pundt N, Pap T, Hoffmann O, Gasser J, Scheinecker C, Smolen JS, van den Berg W, Schett G. Zwerina J, et al. Among authors: hess a. Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11742-7. doi: 10.1073/pnas.0610812104. Epub 2007 Jul 3. Proc Natl Acad Sci U S A. 2007. PMID: 17609389 Free PMC article.
Blockade of TNF-α rapidly inhibits pain responses in the central nervous system.
Hess A, Axmann R, Rech J, Finzel S, Heindl C, Kreitz S, Sergeeva M, Saake M, Garcia M, Kollias G, Straub RH, Sporns O, Doerfler A, Brune K, Schett G. Hess A, et al. Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3731-6. doi: 10.1073/pnas.1011774108. Epub 2011 Jan 18. Proc Natl Acad Sci U S A. 2011. PMID: 21245297 Free PMC article. Clinical Trial.
The alpha-isoform of p38 MAPK specifically regulates arthritic bone loss.
Böhm C, Hayer S, Kilian A, Zaiss MM, Finger S, Hess A, Engelke K, Kollias G, Krönke G, Zwerina J, Schett G, David JP. Böhm C, et al. Among authors: hess a. J Immunol. 2009 Nov 1;183(9):5938-47. doi: 10.4049/jimmunol.0901026. Epub 2009 Oct 14. J Immunol. 2009. PMID: 19828631
RSK2 protects mice against TNF-induced bone loss.
Böhm C, Derer A, Axmann R, Hillienhoff U, Zaiss MM, Luther J, Zech C, Stock M, Scholtysek C, Engelke K, Hess A, Tuckermann JP, Schett G, David JP. Böhm C, et al. Among authors: hess a. J Cell Sci. 2012 May 1;125(Pt 9):2160-71. doi: 10.1242/jcs.096008. Epub 2012 Feb 17. J Cell Sci. 2012. PMID: 22344264
The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts.
Friščić J, Böttcher M, Reinwald C, Bruns H, Wirth B, Popp SJ, Walker KI, Ackermann JA, Chen X, Turner J, Zhu H, Seyler L, Euler M, Kirchner P, Krüger R, Ekici AB, Major T, Aust O, Weidner D, Fischer A, Andes FT, Stanojevic Z, Trajkovic V, Herrmann M, Korb-Pap A, Wank I, Hess A, Winter J, Wixler V, Distler J, Steiner G, Kiener HP, Frey B, Kling L, Raza K, Frey S, Kleyer A, Bäuerle T, Hughes TR, Grüneboom A, Steffen U, Krönke G, Croft AP, Filer A, Köhl J, Klein K, Buckley CD, Schett G, Mougiakakos D, Hoffmann MH. Friščić J, et al. Among authors: hess a. Immunity. 2021 May 11;54(5):1002-1021.e10. doi: 10.1016/j.immuni.2021.03.003. Epub 2021 Mar 23. Immunity. 2021. PMID: 33761330 Free article.
PPARβ/δ governs Wnt signaling and bone turnover.
Scholtysek C, Katzenbeisser J, Fu H, Uderhardt S, Ipseiz N, Stoll C, Zaiss MM, Stock M, Donhauser L, Böhm C, Kleyer A, Hess A, Engelke K, David JP, Djouad F, Tuckermann JP, Desvergne B, Schett G, Krönke G. Scholtysek C, et al. Among authors: hess a. Nat Med. 2013 May;19(5):608-13. doi: 10.1038/nm.3146. Epub 2013 Mar 31. Nat Med. 2013. PMID: 23542786
1,097 results