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Gradual decline in malaria-specific memory T cell responses leads to failure to maintain long-term protective immunity to Plasmodium chabaudi AS despite persistence of B cell memory and circulating antibody.
Freitas do Rosário AP, Muxel SM, Rodríguez-Málaga SM, Sardinha LR, Zago CA, Castillo-Méndez SI, Alvarez JM, D'Império Lima MR. Freitas do Rosário AP, et al. J Immunol. 2008 Dec 15;181(12):8344-55. doi: 10.4049/jimmunol.181.12.8344. J Immunol. 2008. PMID: 19050251
Comparative analysis of activation phenotype, proliferation, and IFN-gamma production by spleen NK1.1(+) and NK1.1(-) T cells during Plasmodium chabaudi AS malaria.
Muxel SM, Freitas do Rosário AP, Sardinha LR, Castillo-Méndez SI, Zago CA, Rodriguez-Málaga SM, Alvarez Mosig JM, D'Império Lima MR. Muxel SM, et al. Among authors: freitas do rosario ap. J Interferon Cytokine Res. 2010 Jun;30(6):417-26. doi: 10.1089/jir.2009.0095. J Interferon Cytokine Res. 2010. PMID: 20187775 Free PMC article.
Anti-IL-2 treatment impairs the expansion of T(reg) cell population during acute malaria and enhances the Th1 cell response at the chronic disease.
Zago CA, Bortoluci KR, Sardinha LR, Pretel FD, Castillo-Méndez SI, Freitas do Rosário AP, Hiyane MI, Muxel SM, Rodriguez-Málaga SM, Abrahamsohn IA, Álvarez JM, D'Império Lima MR. Zago CA, et al. Among authors: freitas do rosario ap. PLoS One. 2012;7(1):e29894. doi: 10.1371/journal.pone.0029894. Epub 2012 Jan 17. PLoS One. 2012. PMID: 22272258 Free PMC article.
T Cell-Derived IL-10 Impairs Host Resistance to Mycobacterium tuberculosis Infection.
Moreira-Teixeira L, Redford PS, Stavropoulos E, Ghilardi N, Maynard CL, Weaver CT, Freitas do Rosário AP, Wu X, Langhorne J, O'Garra A. Moreira-Teixeira L, et al. Among authors: freitas do rosario ap. J Immunol. 2017 Jul 15;199(2):613-623. doi: 10.4049/jimmunol.1601340. Epub 2017 Jun 5. J Immunol. 2017. PMID: 28584007 Free PMC article.