Kim IW - Search Results

1

Sipholenol A, a marine-derived sipholane triterpene, potently reverses P-glycoprotein (ABCB1)-mediated multidrug resistance in cancer cells.

Shi Z, Jain S, Kim IW, Peng XX, Abraham I, Youssef DT, Fu LW, El Sayed K, Ambudkar SV, Chen ZS. Shi Z, et al. Among authors: kim iw. Cancer Sci. 2007 Sep;98(9):1373-80. doi: 10.1111/j.1349-7006.2007.00554.x. Epub 2007 Jul 19. Cancer Sci. 2007. PMID: 17640301 Free PMC article.

2

The power of the pump: mechanisms of action of P-glycoprotein (ABCB1).

Ambudkar SV, Kim IW, Sauna ZE. Ambudkar SV, et al. Among authors: kim iw. Eur J Pharm Sci. 2006 Apr;27(5):392-400. doi: 10.1016/j.ejps.2005.10.010. Epub 2005 Dec 13. Eur J Pharm Sci. 2006. PMID: 16352426 Review.

3

The A-loop, a novel conserved aromatic acid subdomain upstream of the Walker A motif in ABC transporters, is critical for ATP binding.

Ambudkar SV, Kim IW, Xia D, Sauna ZE. Ambudkar SV, et al. Among authors: kim iw. FEBS Lett. 2006 Feb 13;580(4):1049-55. doi: 10.1016/j.febslet.2005.12.051. Epub 2005 Dec 22. FEBS Lett. 2006. PMID: 16412422 Free article. Review.

4

The conserved tyrosine residues 401 and 1044 in ATP sites of human P-glycoprotein are critical for ATP binding and hydrolysis: evidence for a conserved subdomain, the A-loop in the ATP-binding cassette.

Kim IW, Peng XH, Sauna ZE, FitzGerald PC, Xia D, Müller M, Nandigama K, Ambudkar SV. Kim IW, et al. Biochemistry. 2006 Jun 20;45(24):7605-16. doi: 10.1021/bi060308o. Biochemistry. 2006. PMID: 16768456

5

A "silent" polymorphism in the MDR1 gene changes substrate specificity.

Kimchi-Sarfaty C, Oh JM, Kim IW, Sauna ZE, Calcagno AM, Ambudkar SV, Gottesman MM. Kimchi-Sarfaty C, et al. Among authors: kim iw. Science. 2007 Jan 26;315(5811):525-8. doi: 10.1126/science.1135308. Epub 2006 Dec 21. Science. 2007. PMID: 17185560

6

ABC drug transporters as molecular targets for the prevention of multidrug resistance and drug-drug interactions.

Calcagno AM, Kim IW, Wu CP, Shukla S, Ambudkar SV. Calcagno AM, et al. Among authors: kim iw. Curr Drug Deliv. 2007 Oct;4(4):324-33. doi: 10.2174/156720107782151241. Curr Drug Deliv. 2007. PMID: 17979652 Review.

7

Catalytic cycle of ATP hydrolysis by P-glycoprotein: evidence for formation of the E.S reaction intermediate with ATP-gamma-S, a nonhydrolyzable analogue of ATP.

Sauna ZE, Kim IW, Nandigama K, Kopp S, Chiba P, Ambudkar SV. Sauna ZE, et al. Among authors: kim iw. Biochemistry. 2007 Dec 4;46(48):13787-99. doi: 10.1021/bi701385t. Epub 2007 Nov 8. Biochemistry. 2007. PMID: 17988154

8

Erlotinib (Tarceva, OSI-774) antagonizes ATP-binding cassette subfamily B member 1 and ATP-binding cassette subfamily G member 2-mediated drug resistance.

Shi Z, Peng XX, Kim IW, Shukla S, Si QS, Robey RW, Bates SE, Shen T, Ashby CR Jr, Fu LW, Ambudkar SV, Chen ZS. Shi Z, et al. Among authors: kim iw. Cancer Res. 2007 Nov 15;67(22):11012-20. doi: 10.1158/0008-5472.CAN-07-2686. Cancer Res. 2007. PMID: 18006847

9

Genomics and the mechanism of P-glycoprotein (ABCB1).

Sauna ZE, Kim IW, Ambudkar SV. Sauna ZE, et al. Among authors: kim iw. J Bioenerg Biomembr. 2007 Dec;39(5-6):481-7. doi: 10.1007/s10863-007-9115-9. J Bioenerg Biomembr. 2007. PMID: 18058211 Review.

10

Relationship between drugs and functional activity of various mammalian P-glycoproteins (ABCB1).

Kim IW, Booth-Genthe C, Ambudkar SV. Kim IW, et al. Mini Rev Med Chem. 2008 Mar;8(3):193-200. doi: 10.2174/138955708783744100. Mini Rev Med Chem. 2008. PMID: 18336339 Review.

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