Nagaoka M - Search Results

1

Mass spectrometric analysis of oxygenations in aromatization of androst-4-ene-3,6,17-trione, a suicide substrate of aromatase, by placental microsomes. Isotope effect and stereochemistry.

Numazawa M, Takahashi M, Nagaoka M, Handa W, Yamashita K. Numazawa M, et al. Among authors: nagaoka m. J Steroid Biochem Mol Biol. 2007 Nov-Dec;107(3-5):220-7. doi: 10.1016/j.jsbmb.2007.03.041. Epub 2007 Jun 22. J Steroid Biochem Mol Biol. 2007. PMID: 17651966

2

Gas chromatography-mass spectrometric analysis of oxidative reactions of [19,19-(2)H(2)]19-hydroxy-3-deoxy androgens by placental aromatase. bsence of a deuterium-isotope effect.

Nagaoka M, Numazawa M. Nagaoka M, et al. Steroids. 2005 Nov;70(12):831-9. doi: 10.1016/j.steroids.2005.04.009. Steroids. 2005. PMID: 16002112

3

Aromatase reaction of 3-deoxyandrogens: steric mode of the C-19 oxygenation and cleavage of the C10-C19 bond by human placental aromatase.

Numazawa M, Nagaoka M, Sohtome N. Numazawa M, et al. Among authors: nagaoka m. Biochemistry. 2005 Aug 16;44(32):10839-45. doi: 10.1021/bi0508744. Biochemistry. 2005. PMID: 16086586

4

Gas chromatography-mass spectrometric study of 19-oxygenation of the aromatase inhibitor 19-methylandrostenedione with human placental microsomes.

Numazawa M, Nagaoka M, Handa W, Yamada A. Numazawa M, et al. Among authors: nagaoka m. Biol Pharm Bull. 2006 Jun;29(6):1242-5. doi: 10.1248/bpb.29.1242. Biol Pharm Bull. 2006. PMID: 16755025 Free article.

5

Studies directed towards a mechanistic evaluation of inactivation of aromatase by the suicide substrates androsta-1,4-diene-3,17-diones and its 6-ene derivatives aromatase inactivation by the 19-substituted derivatives and their enzymic aromatization.

Numazawa M, Nagaoka M, Handa W, Ogawa Y, Matsuoka S. Numazawa M, et al. Among authors: nagaoka m. J Steroid Biochem Mol Biol. 2007 Nov-Dec;107(3-5):211-9. doi: 10.1016/j.jsbmb.2007.03.042. Epub 2007 Jun 22. J Steroid Biochem Mol Biol. 2007. PMID: 17656084

6

Aromatization of androstenedione and 16alpha-hydroxyandrostenedione in human placental microsomes. Kinetic analysis of inhibition by the 19-oxygenated and 3-deoxy analogs.

Numazawa M, Watari Y, Komatsu S, Yamashita K, Nagaoka M. Numazawa M, et al. Among authors: nagaoka m. Steroids. 2008 Nov;73(12):1262-9. doi: 10.1016/j.steroids.2008.06.001. Epub 2008 Jun 21. Steroids. 2008. PMID: 18611405

7

Metabolic aspects of the 1 beta-proton and the 19-methyl group of androst-4-ene-3,6,17-trione during aromatization by placental microsomes and inactivation of aromatase.

Numazawa M, Midzuhashi K, Nagaoka M. Numazawa M, et al. Among authors: nagaoka m. Biochem Pharmacol. 1994 Feb 11;47(4):717-26. doi: 10.1016/0006-2952(94)90135-x. Biochem Pharmacol. 1994. PMID: 8129748

8

Aromatization of 19-oxygenated androst-4-ene-3,6,17-triones with human placental microsomes.

Numazawa M, Sugiyama T, Nagaoka M. Numazawa M, et al. Among authors: nagaoka m. Biol Pharm Bull. 1998 Mar;21(3):289-92. doi: 10.1248/bpb.21.289. Biol Pharm Bull. 1998. PMID: 9556162 Free article.

9

19-oxygenations of 3-deoxy androgens, potent competitive inhibitors of estrogen biosynthesis, with human placental aromatase.

Numazawa M, Nagaoka M, Morio M, Kamiyama T. Numazawa M, et al. Among authors: nagaoka m. J Steroid Biochem Mol Biol. 1999 Dec 31;71(5-6):173-9. doi: 10.1016/s0960-0760(99)00142-9. J Steroid Biochem Mol Biol. 1999. PMID: 10704906

10

Gas chromatography-mass spectrometric determination of activity of human placental aromatase using 16alpha-hydroxyandrostenedione as a substrate.

Numazawa M, Yoshimura A, Nagaoka M. Numazawa M, et al. Among authors: nagaoka m. Biol Pharm Bull. 2001 May;24(5):564-6. doi: 10.1248/bpb.24.564. Biol Pharm Bull. 2001. PMID: 11379781 Free article.

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