Numazawa M - Search Results

1

Mass spectrometric analysis of oxygenations in aromatization of androst-4-ene-3,6,17-trione, a suicide substrate of aromatase, by placental microsomes. Isotope effect and stereochemistry.

Numazawa M, Takahashi M, Nagaoka M, Handa W, Yamashita K. Numazawa M, et al. J Steroid Biochem Mol Biol. 2007 Nov-Dec;107(3-5):220-7. doi: 10.1016/j.jsbmb.2007.03.041. Epub 2007 Jun 22. J Steroid Biochem Mol Biol. 2007. PMID: 17651966

2

Gas chromatography-mass spectrometric analysis of oxidative reactions of [19,19-(2)H(2)]19-hydroxy-3-deoxy androgens by placental aromatase. bsence of a deuterium-isotope effect.

Nagaoka M, Numazawa M. Nagaoka M, et al. Among authors: numazawa m. Steroids. 2005 Nov;70(12):831-9. doi: 10.1016/j.steroids.2005.04.009. Steroids. 2005. PMID: 16002112

3

Aromatase reaction of 3-deoxyandrogens: steric mode of the C-19 oxygenation and cleavage of the C10-C19 bond by human placental aromatase.

Numazawa M, Nagaoka M, Sohtome N. Numazawa M, et al. Biochemistry. 2005 Aug 16;44(32):10839-45. doi: 10.1021/bi0508744. Biochemistry. 2005. PMID: 16086586

4

Structure-activity relationships of 2alpha-substituted androstenedione analogs as aromatase inhibitors and their aromatization reactions.

Numazawa M, Handa W, Hasegawa C, Takahashi M. Numazawa M, et al. J Steroid Biochem Mol Biol. 2005 Dec;97(4):353-9. doi: 10.1016/j.jsbmb.2005.06.029. Epub 2005 Oct 4. J Steroid Biochem Mol Biol. 2005. PMID: 16209922

5

Gas chromatography-mass spectrometric study of 19-oxygenation of the aromatase inhibitor 19-methylandrostenedione with human placental microsomes.

Numazawa M, Nagaoka M, Handa W, Yamada A. Numazawa M, et al. Biol Pharm Bull. 2006 Jun;29(6):1242-5. doi: 10.1248/bpb.29.1242. Biol Pharm Bull. 2006. PMID: 16755025 Free article.

6

Biochemical aromatization of 2-methyleneandrostenedione: stereochemistry of hydrogen removal at the C-1 position.

Numazawa M, Handa W, Matsuzaki H. Numazawa M, et al. J Steroid Biochem Mol Biol. 2006 Nov;101(4-5):239-45. doi: 10.1016/j.jsbmb.2006.06.026. Epub 2006 Sep 18. J Steroid Biochem Mol Biol. 2006. PMID: 16979892

7

Studies directed towards a mechanistic evaluation of inactivation of aromatase by the suicide substrates androsta-1,4-diene-3,17-diones and its 6-ene derivatives aromatase inactivation by the 19-substituted derivatives and their enzymic aromatization.

Numazawa M, Nagaoka M, Handa W, Ogawa Y, Matsuoka S. Numazawa M, et al. J Steroid Biochem Mol Biol. 2007 Nov-Dec;107(3-5):211-9. doi: 10.1016/j.jsbmb.2007.03.042. Epub 2007 Jun 22. J Steroid Biochem Mol Biol. 2007. PMID: 17656084

8

Aromatization of androstenedione and 16alpha-hydroxyandrostenedione in human placental microsomes. Kinetic analysis of inhibition by the 19-oxygenated and 3-deoxy analogs.

Numazawa M, Watari Y, Komatsu S, Yamashita K, Nagaoka M. Numazawa M, et al. Steroids. 2008 Nov;73(12):1262-9. doi: 10.1016/j.steroids.2008.06.001. Epub 2008 Jun 21. Steroids. 2008. PMID: 18611405

9

Aromatase inactivation by 2-substituted derivatives of the suicide substrate androsta-1,4-diene-3,17-dione.

Takahashi M, Handa W, Umeta H, Ishikawa S, Yamashita K, Numazawa M. Takahashi M, et al. Among authors: numazawa m. J Steroid Biochem Mol Biol. 2009 Sep;116(3-5):191-9. doi: 10.1016/j.jsbmb.2009.05.015. Epub 2009 Jun 9. J Steroid Biochem Mol Biol. 2009. PMID: 19520161

10

Assay of labile estrogen o-quinones, potent carcinogenic molecular species, by high performance liquid chromatography-electrospray ionization tandem mass spectrometry with phenazine derivatization.

Yamashita K, Masuda A, Hoshino Y, Komatsu S, Numazawa M. Yamashita K, et al. Among authors: numazawa m. J Steroid Biochem Mol Biol. 2010 Apr;119(3-5):141-8. doi: 10.1016/j.jsbmb.2010.02.016. Epub 2010 Feb 25. J Steroid Biochem Mol Biol. 2010. PMID: 20188833

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