Deng Y - Search Results

1

Pharmacokinetics and pharmacodynamics of DPC 333 ((2R)-2-((3R)-3-amino-3{4-[2-methyl-4-quinolinyl) methoxy] phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide)), a potent and selective inhibitor of tumor necrosis factor alpha-converting enzyme in rodents, dogs, chimpanzees, and humans.

Qian M, Bai SA, Brogdon B, Wu JT, Liu RQ, Covington MB, Vaddi K, Newton RC, Fossler MJ, Garner CE, Deng Y, Maduskuie T, Trzaskos J, Duan JJ, Decicco CP, Christ DD. Qian M, et al. Among authors: deng y. Drug Metab Dispos. 2007 Oct;35(10):1916-25. doi: 10.1124/dmd.107.015933. Epub 2007 Jul 26. Drug Metab Dispos. 2007. PMID: 17656469 Clinical Trial.

2

High-speed liquid chromatography/tandem mass spectrometry using a monolithic column for high-throughput bioanalysis.

Wu JT, Zeng H, Deng Y, Unger SE. Wu JT, et al. Among authors: deng y. Rapid Commun Mass Spectrom. 2001;15(13):1113-9. doi: 10.1002/rcm.348. Rapid Commun Mass Spectrom. 2001. PMID: 11404848

3

Multiple-sprayer tandem mass spectrometry with parallel high flow extraction and parallel separation for high-throughput quantitation in biological fluids.

Deng Y, Zeng H, Unger SE, Wu JT. Deng Y, et al. Rapid Commun Mass Spectrom. 2001;15(17):1634-40. doi: 10.1002/rcm.422. Rapid Commun Mass Spectrom. 2001. PMID: 11544604

4

High-speed gradient parallel liquid chromatography/tandem mass spectrometry with fully automated sample preparation for bioanalysis: 30 seconds per sample from plasma.

Deng Y, Wu JT, Lloyd TL, Chi CL, Olah TV, Unger SE. Deng Y, et al. Rapid Commun Mass Spectrom. 2002;16(11):1116-23. doi: 10.1002/rcm.688. Rapid Commun Mass Spectrom. 2002. PMID: 11992516

5

Fast analysis using monolithic columns coupled with high-flow on-line extraction and electrospray mass spectrometric detection for the direct and simultaneous quantitation of multiple components in plasma.

Zeng H, Deng Y, Wu JT. Zeng H, et al. Among authors: deng y. J Chromatogr B Analyt Technol Biomed Life Sci. 2003 May 25;788(2):331-7. doi: 10.1016/s1570-0232(03)00040-0. J Chromatogr B Analyt Technol Biomed Life Sci. 2003. PMID: 12705973

6

Quantitation of drug metabolites in the absence of pure metabolite standards by high-performance liquid chromatography coupled with a chemiluminescence nitrogen detector and mass spectrometer.

Deng Y, Wu JT, Zhang H, Olah TV. Deng Y, et al. Rapid Commun Mass Spectrom. 2004;18(15):1681-5. doi: 10.1002/rcm.1540. Rapid Commun Mass Spectrom. 2004. PMID: 15282765

7

Tandem mass spectrometry with online high-flow reversed-phase extraction and normal-phase chromatography on silica columns with aqueous-organic mobile phase for quantitation of polar compounds in biological fluids.

Deng Y, Zhang H, Wu JT, Olah TV. Deng Y, et al. Rapid Commun Mass Spectrom. 2005;19(20):2929-34. doi: 10.1002/rcm.2144. Rapid Commun Mass Spectrom. 2005. PMID: 16175657

8

N-in-1 dosing pharmacokinetics in drug discovery: experience, theoretical and practical considerations.

He K, Qian M, Wong H, Bai SA, He B, Brogdon B, Grace JE, Xin B, Wu J, Ren SX, Zeng H, Deng Y, Graden DM, Olah TV, Unger SE, Luettgen JM, Knabb RM, Pinto DJ, Lam PY, Duan J, Wexler RR, Decicco CP, Christ DD, Grossman SJ. He K, et al. Among authors: deng y. J Pharm Sci. 2008 Jul;97(7):2568-80. doi: 10.1002/jps.21196. J Pharm Sci. 2008. PMID: 17914718

9

Interplay of dissolution, solubility, and nonsink permeation determines the oral absorption of the Hedgehog pathway inhibitor GDC-0449 in dogs: an investigation using preclinical studies and physiologically based pharmacokinetic modeling.

Wong H, Theil FP, Cui Y, Marsters JC Jr, Khojasteh SC, Vernillet L, La H, Song X, Wang H, Morinello EJ, Deng Y, Hop CE. Wong H, et al. Among authors: deng y. Drug Metab Dispos. 2010 Jul;38(7):1029-38. doi: 10.1124/dmd.110.032680. Epub 2010 Apr 20. Drug Metab Dispos. 2010. PMID: 20406853

10

Preclinical disposition of GDC-0973 and prospective and retrospective analysis of human dose and efficacy predictions.

Choo EF, Belvin M, Boggs J, Deng Y, Hoeflich KP, Ly J, Merchant M, Orr C, Plise E, Robarge K, Martini JF, Kassees R, Aoyama RG, Ramaiya A, Johnston SH. Choo EF, et al. Among authors: deng y. Drug Metab Dispos. 2012 May;40(5):919-27. doi: 10.1124/dmd.111.043778. Epub 2012 Feb 7. Drug Metab Dispos. 2012. PMID: 22315332

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