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Pharmacokinetics and pharmacodynamics of DPC 333 ((2R)-2-((3R)-3-amino-3{4-[2-methyl-4-quinolinyl) methoxy] phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide)), a potent and selective inhibitor of tumor necrosis factor alpha-converting enzyme in rodents, dogs, chimpanzees, and humans.
Qian M, Bai SA, Brogdon B, Wu JT, Liu RQ, Covington MB, Vaddi K, Newton RC, Fossler MJ, Garner CE, Deng Y, Maduskuie T, Trzaskos J, Duan JJ, Decicco CP, Christ DD. Qian M, et al. Among authors: garner ce. Drug Metab Dispos. 2007 Oct;35(10):1916-25. doi: 10.1124/dmd.107.015933. Epub 2007 Jul 26. Drug Metab Dispos. 2007. PMID: 17656469 Clinical Trial.
Effect of DPC 333 [(2R)-2-{(3R)-3-amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a human tumor necrosis factor alpha-converting enzyme inhibitor, on the disposition of methotrexate: a transporter-based drug-drug interaction case study.
Luo G, Garner CE, Xiong H, Hu H, Richards LE, Brouwer KL, Duan J, Decicco CP, Maduskuie T, Shen H, Lee FW, Gan LS. Luo G, et al. Among authors: garner ce. Drug Metab Dispos. 2007 Jun;35(6):835-40. doi: 10.1124/dmd.106.013946. Epub 2007 Mar 1. Drug Metab Dispos. 2007. PMID: 17332143
Role of P-glycoprotein and the intestine in the excretion of DPC 333 [(2R)-2-{(3R)-3-amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide] in rodents.
Garner CE, Solon E, Lai CM, Lin J, Luo G, Jones K, Duan J, Decicco CP, Maduskuie T, Mercer SE, Gan LS, Qian M, Prakash S, Shen HS, Lee FW. Garner CE, et al. Drug Metab Dispos. 2008 Jun;36(6):1102-10. doi: 10.1124/dmd.107.017038. Epub 2008 Mar 17. Drug Metab Dispos. 2008. PMID: 18347085
Dose and gender dependence of chlorine inhalation in a conscious ovine model.
Baljinnyam T, Niimi Y, Salsbury JR, Fukuda S, Ouellette CM, Andersen CR, Hirasawa Y, Prough DA, Garner CE, Salzman AL, Enkhbaatar P. Baljinnyam T, et al. Among authors: garner ce. Sci Rep. 2023 Dec 15;13(1):22367. doi: 10.1038/s41598-023-48720-2. Sci Rep. 2023. PMID: 38102196 Free PMC article.
44 results