Wu JT - Search Results

1

Pharmacokinetics and pharmacodynamics of DPC 333 ((2R)-2-((3R)-3-amino-3{4-[2-methyl-4-quinolinyl) methoxy] phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide)), a potent and selective inhibitor of tumor necrosis factor alpha-converting enzyme in rodents, dogs, chimpanzees, and humans.

Qian M, Bai SA, Brogdon B, Wu JT, Liu RQ, Covington MB, Vaddi K, Newton RC, Fossler MJ, Garner CE, Deng Y, Maduskuie T, Trzaskos J, Duan JJ, Decicco CP, Christ DD. Qian M, et al. Among authors: wu jt. Drug Metab Dispos. 2007 Oct;35(10):1916-25. doi: 10.1124/dmd.107.015933. Epub 2007 Jul 26. Drug Metab Dispos. 2007. PMID: 17656469 Clinical Trial.

2

N-in-1 dosing pharmacokinetics in drug discovery: experience, theoretical and practical considerations.

He K, Qian M, Wong H, Bai SA, He B, Brogdon B, Grace JE, Xin B, Wu J, Ren SX, Zeng H, Deng Y, Graden DM, Olah TV, Unger SE, Luettgen JM, Knabb RM, Pinto DJ, Lam PY, Duan J, Wexler RR, Decicco CP, Christ DD, Grossman SJ. He K, et al. J Pharm Sci. 2008 Jul;97(7):2568-80. doi: 10.1002/jps.21196. J Pharm Sci. 2008. PMID: 17914718

3

Development of a dog microdialysis model for determining synovial fluid pharmacokinetics of anti-arthritis compounds exemplified by methotrexate.

Qian M, West W, Wu JT, Lu B, Christ DD. Qian M, et al. Among authors: wu jt. Pharm Res. 2003 Apr;20(4):605-10. doi: 10.1023/a:1023246832321. Pharm Res. 2003. PMID: 12739768

4

Fast analysis using monolithic columns coupled with high-flow on-line extraction and electrospray mass spectrometric detection for the direct and simultaneous quantitation of multiple components in plasma.

Zeng H, Deng Y, Wu JT. Zeng H, et al. Among authors: wu jt. J Chromatogr B Analyt Technol Biomed Life Sci. 2003 May 25;788(2):331-7. doi: 10.1016/s1570-0232(03)00040-0. J Chromatogr B Analyt Technol Biomed Life Sci. 2003. PMID: 12705973

5

Tandem mass spectrometry with online high-flow reversed-phase extraction and normal-phase chromatography on silica columns with aqueous-organic mobile phase for quantitation of polar compounds in biological fluids.

Deng Y, Zhang H, Wu JT, Olah TV. Deng Y, et al. Among authors: wu jt. Rapid Commun Mass Spectrom. 2005;19(20):2929-34. doi: 10.1002/rcm.2144. Rapid Commun Mass Spectrom. 2005. PMID: 16175657

6

Quantitation of drug metabolites in the absence of pure metabolite standards by high-performance liquid chromatography coupled with a chemiluminescence nitrogen detector and mass spectrometer.

Deng Y, Wu JT, Zhang H, Olah TV. Deng Y, et al. Among authors: wu jt. Rapid Commun Mass Spectrom. 2004;18(15):1681-5. doi: 10.1002/rcm.1540. Rapid Commun Mass Spectrom. 2004. PMID: 15282765

7

High-speed gradient parallel liquid chromatography/tandem mass spectrometry with fully automated sample preparation for bioanalysis: 30 seconds per sample from plasma.

Deng Y, Wu JT, Lloyd TL, Chi CL, Olah TV, Unger SE. Deng Y, et al. Among authors: wu jt. Rapid Commun Mass Spectrom. 2002;16(11):1116-23. doi: 10.1002/rcm.688. Rapid Commun Mass Spectrom. 2002. PMID: 11992516

8

Effective dosing regimen of 1-aminobenzotriazole for inhibition of antipyrine clearance in guinea pigs and mice using serial sampling.

Balani SK, Li P, Nguyen J, Cardoza K, Zeng H, Mu DX, Wu JT, Gan LS, Lee FW. Balani SK, et al. Among authors: wu jt. Drug Metab Dispos. 2004 Oct;32(10):1092-5. doi: 10.1124/dmd.104.000349. Epub 2004 Jun 24. Drug Metab Dispos. 2004. PMID: 15217988

9

An indirect screen for brain uptake of 1,2-diarylethane melanocortin 4 receptor antagonists in rats.

Yin W, Gan LS, Wu JT, Balani SK, Yang H, Lee FW. Yin W, et al. Among authors: wu jt. Drug Metab Lett. 2007 Aug;1(3):195-8. doi: 10.2174/187231207781369753. Drug Metab Lett. 2007. PMID: 19356043

10

P-glycoprotein and breast cancer resistance protein affect disposition of tandutinib, a tyrosine kinase inhibitor.

Yang JJ, Milton MN, Yu S, Liao M, Liu N, Wu JT, Gan L, Balani SK, Lee FW, Prakash S, Xia CQ. Yang JJ, et al. Among authors: wu jt. Drug Metab Lett. 2010 Dec;4(4):201-12. doi: 10.2174/187231210792928279. Drug Metab Lett. 2010. PMID: 20670210

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