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P16(INK4A) immunostaining is a strong indicator for high-risk-HPV-associated oropharyngeal carcinomas and dysplasias, but is unreliable to predict low-risk-HPV-infection in head and neck papillomas and laryngeal dysplasias.
Mooren JJ, Gültekin SE, Straetmans JM, Haesevoets A, Peutz-Kootstra CJ, Huebbers CU, Dienes HP, Wieland U, Ramaekers FC, Kremer B, Speel EJ, Klussmann JP. Mooren JJ, et al. Among authors: speel ej. Int J Cancer. 2014 May 1;134(9):2108-17. doi: 10.1002/ijc.28534. Epub 2013 Oct 21. Int J Cancer. 2014. PMID: 24127203
Human papillomavirus multiplex ligation-dependent probe amplification assay for the assessment of viral load, integration, and gain of telomerase-related genes in cervical malignancies.
Theelen W, Litjens RJ, Vinokurova S, Haesevoets A, Reijans M, Simons G, Smedts F, Herrington CS, Ramaekers FC, von Knebel Doeberitz M, Speel EJ, Hopman AH. Theelen W, et al. Among authors: speel ej. Hum Pathol. 2013 Nov;44(11):2410-8. doi: 10.1016/j.humpath.2013.04.026. Epub 2013 Aug 19. Hum Pathol. 2013. PMID: 23968641 Free article.
Comprehensive analysis of HPV16 integration in OSCC reveals no significant impact of physical status on viral oncogene and virally disrupted human gene expression.
Olthof NC, Speel EJ, Kolligs J, Haesevoets A, Henfling M, Ramaekers FC, Preuss SF, Drebber U, Wieland U, Silling S, Lam WL, Vucic EA, Kremer B, Klussmann JP, Huebbers CU. Olthof NC, et al. Among authors: speel ej. PLoS One. 2014 Feb 24;9(2):e88718. doi: 10.1371/journal.pone.0088718. eCollection 2014. PLoS One. 2014. PMID: 24586376 Free PMC article.
Validation of a gene expression signature for assessment of lymph node metastasis in oral squamous cell carcinoma.
van Hooff SR, Leusink FK, Roepman P, Baatenburg de Jong RJ, Speel EJ, van den Brekel MW, van Velthuysen ML, van Diest PJ, van Es RJ, Merkx MA, Kummer JA, Leemans CR, Schuuring E, Langendijk JA, Lacko M, De Herdt MJ, Jansen JC, Brakenhoff RH, Slootweg PJ, Takes RP, Holstege FC. van Hooff SR, et al. Among authors: speel ej. J Clin Oncol. 2012 Nov 20;30(33):4104-10. doi: 10.1200/JCO.2011.40.4509. Epub 2012 Oct 8. J Clin Oncol. 2012. PMID: 23045589
Viral load, gene expression and mapping of viral integration sites in HPV16-associated HNSCC cell lines.
Olthof NC, Huebbers CU, Kolligs J, Henfling M, Ramaekers FC, Cornet I, van Lent-Albrechts JA, Stegmann AP, Silling S, Wieland U, Carey TE, Walline HM, Gollin SM, Hoffmann TK, de Winter J, Kremer B, Klussmann JP, Speel EJ. Olthof NC, et al. Among authors: speel ej. Int J Cancer. 2015 Mar 1;136(5):E207-18. doi: 10.1002/ijc.29112. Epub 2014 Aug 14. Int J Cancer. 2015. PMID: 25082736 Free PMC article.
239 results