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Page 1
Conformational constraint in oxazolidinone antibacterials. Part 2: Synthesis and structure-activity studies of oxa-, aza-, and thiabicyclo[3.1.0]hexylphenyl oxazolidinones.
Renslo AR, Gao H, Jaishankar P, Venkatachalam R, Gómez M, Blais J, Huband M, Vara Prasad JV, Gordeev MF. Renslo AR, et al. Among authors: vara prasad jv. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1126-9. doi: 10.1016/j.bmcl.2005.11.093. Epub 2006 Jan 4. Bioorg Med Chem Lett. 2006. PMID: 16387498
Synthesis and SAR of novel conformationally-restricted oxazolidinones possessing gram-positive and fastidious gram-negative antibacterial activity. Part 1: Substituted pyrazoles.
Boyer FE, Vara Prasad JV, Choy AL, Chupak L, Dermyer MR, Ding Q, Huband MD, Jiao W, Kaneko T, Khlebnikov V, Kim JY, Lall MS, Maiti SN, Romero K, Wu X. Boyer FE, et al. Among authors: vara prasad jv. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4694-8. doi: 10.1016/j.bmcl.2007.05.056. Epub 2007 May 24. Bioorg Med Chem Lett. 2007. PMID: 17590334
Nonpeptidic HIV protease inhibitors: 6-alkyl-5,6-dihydropyran-2-ones possessing a novel and achiral 3-(2-t-butyl-5-methyl-4-sulfamate)phenylthio moiety.
Vara Prasad JV, Markoski LJ, Boyer FE, Domagala JM, Ellsworth EL, Gajda C, Hagen SE, Tait BD, Lunney EA, Tummino PJ, Ferguson D, Holler T, Hupe D, Nouhan C, Gracheck SJ, VanderRoest S, Saunders J, Iyer K, Sinz M. Vara Prasad JV, et al. Bioorg Med Chem Lett. 1999 Aug 2;9(15):2217-22. doi: 10.1016/s0960-894x(99)00360-1. Bioorg Med Chem Lett. 1999. PMID: 10465549
New oxazolidinones.
Vara Prasad JV. Vara Prasad JV. Curr Opin Microbiol. 2007 Oct;10(5):454-60. doi: 10.1016/j.mib.2007.08.001. Epub 2007 Oct 24. Curr Opin Microbiol. 2007. PMID: 17928263 Review.
Nonpeptidic HIV protease inhibitors: 6-alkyl-5,6-dihydropyran-2-ones possessing achiral 3-(4-amino/carboxamide-2-t-butyl,5-methylphenyl thio) moiety: antiviral activities and pharmacokinetic properties.
Vara Prasad JV, Boyer FE, Domagala JM, Ellsworth EL, Gajda C, Hagen SE, Markoski LJ, Tait BD, Lunney EA, Tummino PJ, Ferguson D, Holler T, Hupe D, Nouhan C, Gracheck SJ, VanderRoest S, Saunders J, Iyer K, Sinz M, Brodfuehrer J. Vara Prasad JV, et al. Bioorg Med Chem Lett. 1999 Jun 7;9(11):1481-6. doi: 10.1016/s0960-894x(99)00237-1. Bioorg Med Chem Lett. 1999. PMID: 10386921
5,6-Dihydropyran-2-ones possessing various sulfonyl functionalities: potent nonpeptidic inhibitors of HIV protease.
Boyer FE, Vara Prasad JV, Domagala JM, Ellsworth EL, Gajda C, Hagen SE, Markoski LJ, Tait BD, Lunney EA, Palovsky A, Ferguson D, Graham N, Holler T, Hupe D, Nouhan C, Tummino PJ, Urumov A, Zeikus E, Zeikus G, Gracheck SJ, Sanders JM, VanderRoest S, Brodfuehrer J, Iyer K, Sinz M, Gulnik SV. Boyer FE, et al. Among authors: vara prasad jv. J Med Chem. 2000 Mar 9;43(5):843-58. doi: 10.1021/jm990281p. J Med Chem. 2000. PMID: 10715152
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