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Page 1
Spatial control of protein phosphatase 2A (de)methylation.
Longin S, Zwaenepoel K, Martens E, Louis JV, Rondelez E, Goris J, Janssens V. Longin S, et al. Among authors: louis jv. Exp Cell Res. 2008 Jan 1;314(1):68-81. doi: 10.1016/j.yexcr.2007.07.030. Epub 2007 Aug 7. Exp Cell Res. 2008. PMID: 17803990
Mice lacking phosphatase PP2A subunit PR61/B'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3beta.
Louis JV, Martens E, Borghgraef P, Lambrecht C, Sents W, Longin S, Zwaenepoel K, Pijnenborg R, Landrieu I, Lippens G, Ledermann B, Götz J, Van Leuven F, Goris J, Janssens V. Louis JV, et al. Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6957-62. doi: 10.1073/pnas.1018777108. Epub 2011 Apr 11. Proc Natl Acad Sci U S A. 2011. PMID: 21482799 Free PMC article.
Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1.
Forester CM, Maddox J, Louis JV, Goris J, Virshup DM. Forester CM, et al. Among authors: louis jv. Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19867-72. doi: 10.1073/pnas.0709879104. Epub 2007 Dec 4. Proc Natl Acad Sci U S A. 2007. PMID: 18056802 Free PMC article.
GSK3 and Alzheimer's Disease: Facts and Fiction….
Kremer A, Louis JV, Jaworski T, Van Leuven F. Kremer A, et al. Among authors: louis jv. Front Mol Neurosci. 2011 Aug 26;4:17. doi: 10.3389/fnmol.2011.00017. eCollection 2011. Front Mol Neurosci. 2011. PMID: 21904524 Free PMC article.
Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain.
Luo G, Chen L, Kostich WA, Hamman B, Allen J, Easton A, Bourin C, Gulianello M, Lippy J, Nara S, Pattipati SN, Dandapani K, Dokania M, Vattikundala P, Sharma V, Elavazhagan S, Verma MK, Lal Das M, Wagh S, Balakrishnan A, Johnson BM, Santone KS, Thalody G, Denton R, Saminathan H, Holenarsipur VK, Kumar A, Rao A, Putlur SP, Sarvasiddhi SK, Shankar G, Louis JV, Ramarao M, Conway CM, Li YW, Pieschl R, Tian Y, Hong Y, Bristow L, Albright CF, Bronson JJ, Macor JE, Dzierba CD. Luo G, et al. Among authors: louis jv. J Med Chem. 2022 Mar 24;65(6):4534-4564. doi: 10.1021/acs.jmedchem.1c02132. Epub 2022 Mar 9. J Med Chem. 2022. PMID: 35261239
Discovery of (S)-1-((2',6-Bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein-2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain.
Luo G, Chen L, Kostich WA, Hamman B, Allen J, Easton A, Bourin C, Gulianello M, Lippy J, Nara S, Maishal TK, Thiyagarajan K, Jalagam P, Pattipati SN, Dandapani K, Dokania M, Vattikundala P, Sharma V, Elavazhagan S, Verma MK, Das ML, Wagh S, Balakrishnan A, Johnson BM, Santone KS, Thalody G, Denton R, Saminathan H, Holenarsipur VK, Kumar A, Rao A, Putlur SP, Sarvasiddhi SK, Shankar G, Louis JV, Ramarao M, Conway CM, Li YW, Pieschl R, Tian Y, Hong Y, Ditta J, Mathur A, Li J, Smith D, Pawluczyk J, Sun D, Yip S, Wu DR, Vetrichelvan M, Gupta A, Wilson A, Gopinathan S, Wason S, Bristow L, Albright CF, Bronson JJ, Macor JE, Dzierba CD. Luo G, et al. Among authors: louis jv. J Med Chem. 2022 Mar 24;65(6):4457-4480. doi: 10.1021/acs.jmedchem.1c02131. Epub 2022 Mar 8. J Med Chem. 2022. PMID: 35257579
19 results