Merriman RL - Search Results

1

4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase.

Spicer JA, Rewcastle GW, Kaufman MD, Black SL, Plummer MS, Denny WA, Quin J 3rd, Shahripour AB, Barrett SD, Whitehead CE, Milbank JB, Ohren JF, Gowan RC, Omer C, Camp HS, Esmaeil N, Moore K, Sebolt-Leopold JS, Pryzbranowski S, Merriman RL, Ortwine DF, Warmus JS, Flamme CM, Pavlovsky AG, Tecle H. Spicer JA, et al. Among authors: merriman rl. J Med Chem. 2007 Oct 18;50(21):5090-102. doi: 10.1021/jm0704548. Epub 2007 Sep 19. J Med Chem. 2007. PMID: 17880056

2

2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles-O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase).

Warmus JS, Flamme C, Zhang LY, Barrett S, Bridges A, Chen H, Gowan R, Kaufman M, Sebolt-Leopold J, Leopold W, Merriman R, Ohren J, Pavlovsky A, Przybranowski S, Tecle H, Valik H, Whitehead C, Zhang E. Warmus JS, et al. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6171-4. doi: 10.1016/j.bmcl.2008.10.015. Epub 2008 Oct 7. Bioorg Med Chem Lett. 2008. PMID: 18951019

3

Synthesis and evaluation of antitumor activity of novel N-acyllavendamycin analogues and quinoline-5,8-diones.

Behforouz M, Cai W, Mohammadi F, Stocksdale MG, Gu Z, Ahmadian M, Baty DE, Etling MR, Al-Anzi CH, Swiftney TM, Tanzer LR, Merriman RL, Behforouz NC. Behforouz M, et al. Among authors: merriman rl. Bioorg Med Chem. 2007 Jan 1;15(1):495-510. doi: 10.1016/j.bmc.2006.09.039. Epub 2006 Oct 10. Bioorg Med Chem. 2007. PMID: 17035024 Free PMC article.

4

Synthesis and evaluation of hydroxylated polyamine analogues as antiproliferatives.

Bergeron RJ, Müller R, Bussenius J, McManis JS, Merriman RL, Smith RE, Yao H, Weimar WR. Bergeron RJ, et al. Among authors: merriman rl. J Med Chem. 2000 Jan 27;43(2):224-35. doi: 10.1021/jm990375z. J Med Chem. 2000. PMID: 10649978

5

A multiwell assay for inhibitors of phosphatidylinositol-3-kinase and the identification of natural product inhibitors.

Frew T, Powis G, Berggren M, Abraham RT, Ashendel CL, Zalkow LH, Hudson C, Qazia S, Gruszecka-Kowalik E, Merriman R, et al. Frew T, et al. Anticancer Res. 1994 Nov-Dec;14(6B):2425-8. Anticancer Res. 1994. PMID: 7872663

6

In vitro and in vivo antitumor activity of the phosphatidylinositol-3-kinase inhibitor, wortmannin.

Schultz RM, Merriman RL, Andis SL, Bonjouklian R, Grindey GB, Rutherford PG, Gallegos A, Massey K, Powis G. Schultz RM, et al. Among authors: merriman rl. Anticancer Res. 1995 Jul-Aug;15(4):1135-9. Anticancer Res. 1995. PMID: 7653991

7

Inhibition of PAIII rat prostatic adenocarcinoma growth and metastasis by a new diarylsulfonylurea antitumor agent, LY181984.

Neubauer BL, Merriman RL, Best KL, Goode RL, Sarosdy MF, Tanzer LR, Howbert JJ. Neubauer BL, et al. Among authors: merriman rl. J Urol. 1992 Feb;147(2):500-4. doi: 10.1016/s0022-5347(17)37288-9. J Urol. 1992. PMID: 1732631

8

Comparison of the antitumor activity of gemcitabine and ara-C in a panel of human breast, colon, lung and pancreatic xenograft models.

Merriman RL, Hertel LW, Schultz RM, Houghton PJ, Houghton JA, Rutherford PG, Tanzer LR, Boder GB, Grindey GB. Merriman RL, et al. Invest New Drugs. 1996;14(3):243-7. doi: 10.1007/BF00194526. Invest New Drugs. 1996. PMID: 8958178

9

Studies on the mechanism of sulofenur and LY295501 toxicity: effect on the regulation of cytosolic calcium in relation to cytotoxicity in normal and tumorigenic rat kidney cell lines.

Phelps PC, Best CJ, Berezesky IK, Merriman RL, Tanzer LR, Boder GB, Trump BF. Phelps PC, et al. Among authors: merriman rl. Cancer Lett. 1995 Oct 20;97(1):7-15. doi: 10.1016/0304-3835(95)03942-p. Cancer Lett. 1995. PMID: 7585481

10

H-ras-transformed NRK-52E renal epithelial cells have altered growth, morphology, and cytoskeletal structure that correlates with renal cell carcinoma in vivo.

Best CJ, Tanzer LR, Phelps PC, Merriman RL, Boder GG, Trump BF, Elliget KA. Best CJ, et al. Among authors: merriman rl. In Vitro Cell Dev Biol Anim. 1999 Apr;35(4):205-14. doi: 10.1007/s11626-999-0028-2. In Vitro Cell Dev Biol Anim. 1999. PMID: 10478800

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