Hendriks BS - Search Results

1

Analysis of mechanistic pathway models in drug discovery: p38 pathway.

Hendriks BS, Hua F, Chabot JR. Hendriks BS, et al. Biotechnol Prog. 2008 Jan-Feb;24(1):96-109. doi: 10.1021/bp070084g. Epub 2007 Oct 5. Biotechnol Prog. 2008. PMID: 17918858

2

Two additive mechanisms impair the differentiation of 'substrate-selective' p38 inhibitors from classical p38 inhibitors in vitro.

Hendriks BS, Seidl KM, Chabot JR. Hendriks BS, et al. BMC Syst Biol. 2010 Mar 15;4:23. doi: 10.1186/1752-0509-4-23. BMC Syst Biol. 2010. PMID: 20230629 Free PMC article.

3

Multiple effects of acetaminophen and p38 inhibitors: towards pathway toxicology.

Xu JJ, Hendriks BS, Zhao J, de Graaf D. Xu JJ, et al. Among authors: hendriks bs. FEBS Lett. 2008 Apr 9;582(8):1276-82. doi: 10.1016/j.febslet.2008.01.063. Epub 2008 Feb 20. FEBS Lett. 2008. PMID: 18282474 Free article. Review.

4

Applying computational modeling to drug discovery and development.

Kumar N, Hendriks BS, Janes KA, de Graaf D, Lauffenburger DA. Kumar N, et al. Among authors: hendriks bs. Drug Discov Today. 2006 Sep;11(17-18):806-11. doi: 10.1016/j.drudis.2006.07.010. Drug Discov Today. 2006. PMID: 16935748 Review.

5

Elevated GM-CSF and IL-1beta levels compromise the ability of p38 MAPK inhibitors to modulate TNFalpha levels in the human monocytic/macrophage U937 cell line.

Espelin CW, Goldsipe A, Sorger PK, Lauffenburger DA, de Graaf D, Hendriks BS. Espelin CW, et al. Among authors: hendriks bs. Mol Biosyst. 2010 Oct;6(10):1956-72. doi: 10.1039/c002848g. Epub 2010 Jul 9. Mol Biosyst. 2010. PMID: 20617251

6

Cytokine-associated drug toxicity in human hepatocytes is associated with signaling network dysregulation.

Cosgrove BD, Alexopoulos LG, Hang TC, Hendriks BS, Sorger PK, Griffith LG, Lauffenburger DA. Cosgrove BD, et al. Among authors: hendriks bs. Mol Biosyst. 2010 Jul;6(7):1195-206. doi: 10.1039/b926287c. Epub 2010 Apr 1. Mol Biosyst. 2010. PMID: 20361094 Free PMC article.

7

HER2-mediated effects on EGFR endosomal sorting: analysis of biophysical mechanisms.

Hendriks BS, Wiley HS, Lauffenburger D. Hendriks BS, et al. Biophys J. 2003 Oct;85(4):2732-45. doi: 10.1016/S0006-3495(03)74696-7. Biophys J. 2003. PMID: 14507736 Free PMC article.

8

Functional pathway pharmacology: chemical tools, pathway knowledge and mechanistic model-based interpretation of experimental data.

Hendriks BS. Hendriks BS. Curr Opin Chem Biol. 2010 Aug;14(4):489-97. doi: 10.1016/j.cbpa.2010.06.167. Epub 2010 Jul 6. Curr Opin Chem Biol. 2010. PMID: 20609614 Review.

9

Quantitative analysis of HER2-mediated effects on HER2 and epidermal growth factor receptor endocytosis: distribution of homo- and heterodimers depends on relative HER2 levels.

Hendriks BS, Opresko LK, Wiley HS, Lauffenburger D. Hendriks BS, et al. J Biol Chem. 2003 Jun 27;278(26):23343-51. doi: 10.1074/jbc.M300477200. Epub 2003 Apr 9. J Biol Chem. 2003. PMID: 12686539 Free article.

10

Parsing ERK activation reveals quantitatively equivalent contributions from epidermal growth factor receptor and HER2 in human mammary epithelial cells.

Hendriks BS, Orr G, Wells A, Wiley HS, Lauffenburger DA. Hendriks BS, et al. J Biol Chem. 2005 Feb 18;280(7):6157-69. doi: 10.1074/jbc.M410491200. Epub 2004 Nov 29. J Biol Chem. 2005. PMID: 15572377 Free article.

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