Plumb JA - Search Results

1

Phase I and pharmacodynamic trial of the DNA methyltransferase inhibitor decitabine and carboplatin in solid tumors.

Appleton K, Mackay HJ, Judson I, Plumb JA, McCormick C, Strathdee G, Lee C, Barrett S, Reade S, Jadayel D, Tang A, Bellenger K, Mackay L, Setanoians A, Schätzlein A, Twelves C, Kaye SB, Brown R. Appleton K, et al. Among authors: plumb ja. J Clin Oncol. 2007 Oct 10;25(29):4603-9. doi: 10.1200/JCO.2007.10.8688. J Clin Oncol. 2007. PMID: 17925555 Clinical Trial.

2

Demethylation of DNA by decitabine in cancer chemotherapy.

Brown R, Plumb JA. Brown R, et al. Among authors: plumb ja. Expert Rev Anticancer Ther. 2004 Aug;4(4):501-10. doi: 10.1586/14737140.4.4.501. Expert Rev Anticancer Ther. 2004. PMID: 15270655 Review.

3

A phase 1 pharmacokinetic and pharmacodynamic study of the histone deacetylase inhibitor belinostat in patients with advanced solid tumors.

Steele NL, Plumb JA, Vidal L, Tjørnelund J, Knoblauch P, Rasmussen A, Ooi CE, Buhl-Jensen P, Brown R, Evans TR, DeBono JS. Steele NL, et al. Among authors: plumb ja. Clin Cancer Res. 2008 Feb 1;14(3):804-10. doi: 10.1158/1078-0432.CCR-07-1786. Clin Cancer Res. 2008. PMID: 18245542 Clinical Trial.

4

Reversal of drug resistance in human tumor xenografts by 2'-deoxy-5-azacytidine-induced demethylation of the hMLH1 gene promoter.

Plumb JA, Strathdee G, Sludden J, Kaye SB, Brown R. Plumb JA, et al. Cancer Res. 2000 Nov 1;60(21):6039-44. Cancer Res. 2000. PMID: 11085525

5

CpG-island methylation and epigenetic control of resistance to chemotherapy.

Teodoridis JM, Strathdee G, Plumb JA, Brown R. Teodoridis JM, et al. Among authors: plumb ja. Biochem Soc Trans. 2004 Dec;32(Pt 6):916-7. doi: 10.1042/BST0320916. Biochem Soc Trans. 2004. PMID: 15506923 Review.

6

Combined inhibition of DNA methylation and histone acetylation enhances gene re-expression and drug sensitivity in vivo.

Steele N, Finn P, Brown R, Plumb JA. Steele N, et al. Among authors: plumb ja. Br J Cancer. 2009 Mar 10;100(5):758-63. doi: 10.1038/sj.bjc.6604932. Br J Cancer. 2009. PMID: 19259094 Free PMC article.

7

Epigenetic approaches to cancer therapy.

Plumb JA, Steele N, Finn PW, Brown R. Plumb JA, et al. Biochem Soc Trans. 2004 Dec;32(Pt 6):1095-7. doi: 10.1042/BST0321095. Biochem Soc Trans. 2004. PMID: 15506976

8

Pharmacodynamic response and inhibition of growth of human tumor xenografts by the novel histone deacetylase inhibitor PXD101.

Plumb JA, Finn PW, Williams RJ, Bandara MJ, Romero MR, Watkins CJ, La Thangue NB, Brown R. Plumb JA, et al. Mol Cancer Ther. 2003 Aug;2(8):721-8. Mol Cancer Ther. 2003. PMID: 12939461

9

The activity of verapamil as a resistance modifier in vitro in drug resistant human tumour cell lines is not stereospecific.

Plumb JA, Milroy R, Kaye SB. Plumb JA, et al. Biochem Pharmacol. 1990 Feb 15;39(4):787-92. doi: 10.1016/0006-2952(90)90160-m. Biochem Pharmacol. 1990. PMID: 1968341

10

Effects of the pH dependence of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide-formazan absorption on chemosensitivity determined by a novel tetrazolium-based assay.

Plumb JA, Milroy R, Kaye SB. Plumb JA, et al. Cancer Res. 1989 Aug 15;49(16):4435-40. Cancer Res. 1989. PMID: 2743332

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