Adam G - Search Results

1

Synthesis and characterization of 8-ethynyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: new potent non-competitive metabotropic glutamate receptor 2/3 antagonists. Part 1.

Woltering TJ, Adam G, Alanine A, Wichmann J, Knoflach F, Mutel V, Gatti S. Woltering TJ, et al. Among authors: adam g. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6811-5. doi: 10.1016/j.bmcl.2007.10.026. Epub 2007 Oct 17. Bioorg Med Chem Lett. 2007. PMID: 17964783

2

Asymmetric synthesis and receptor pharmacology of the group II mGlu receptor ligand (1S,2R,3R,5R,6S)-2-amino-3-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid-HYDIA.

Woltering TJ, Adam G, Huguenin P, Wichmann J, Kolczewski S, Gatti S, Bourson A, Kew JN, Richards G, Kemp JA, Mutel V, Knoflach F. Woltering TJ, et al. Among authors: adam g. ChemMedChem. 2008 Feb;3(2):323-35. doi: 10.1002/cmdc.200700226. ChemMedChem. 2008. PMID: 18058780

3

Synthesis and characterization of 8-ethynyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: part 2. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists.

Woltering TJ, Adam G, Wichmann J, Goetschi E, Kew JN, Knoflach F, Mutel V, Gatti S. Woltering TJ, et al. Among authors: adam g. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1091-5. doi: 10.1016/j.bmcl.2007.12.005. Epub 2007 Dec 8. Bioorg Med Chem Lett. 2008. PMID: 18096387

4

Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 3. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists.

Woltering TJ, Wichmann J, Goetschi E, Adam G, Kew JN, Knoflach F, Ballard TM, Huwyler J, Mutel V, Gatti S. Woltering TJ, et al. Among authors: adam g. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2725-9. doi: 10.1016/j.bmcl.2008.02.076. Epub 2008 Mar 5. Bioorg Med Chem Lett. 2008. PMID: 18374569

5

Mutational analysis and molecular modeling of the allosteric binding site of a novel, selective, noncompetitive antagonist of the metabotropic glutamate 1 receptor.

Malherbe P, Kratochwil N, Knoflach F, Zenner MT, Kew JN, Kratzeisen C, Maerki HP, Adam G, Mutel V. Malherbe P, et al. Among authors: adam g. J Biol Chem. 2003 Mar 7;278(10):8340-7. doi: 10.1074/jbc.M211759200. Epub 2002 Dec 30. J Biol Chem. 2003. PMID: 12509432 Free article.

6

Structure-activity relationships of substituted 5H-thiazolo[3,2-a]pyrimidines as group 2 metabotropic glutamate receptor antagonists.

Wichmann J, Adam G, Kolczewski S, Mutel V, Woltering T. Wichmann J, et al. Among authors: adam g. Bioorg Med Chem Lett. 1999 Jun 7;9(11):1573-6. doi: 10.1016/s0960-894x(99)00227-9. Bioorg Med Chem Lett. 1999. PMID: 10386938

7

Synthesis of heterocyclic enol ethers and their use as group 2 metabotropic glutamate receptor antagonists.

Kolczewski S, Adam G, Stadler H, Mutel V, Wichmann J, Woltering T. Kolczewski S, et al. Among authors: adam g. Bioorg Med Chem Lett. 1999 Aug 2;9(15):2173-6. doi: 10.1016/s0960-894x(99)00346-7. Bioorg Med Chem Lett. 1999. PMID: 10465539

8

Pharmacological properties of native metabotropic glutamate receptors in freshly dissociated Golgi cells of the rat cerebellum.

Knoflach F, Woltering T, Adam G, Mutel V, Kemp JA. Knoflach F, et al. Among authors: adam g. Neuropharmacology. 2001;40(2):163-9. doi: 10.1016/s0028-3908(00)00152-0. Neuropharmacology. 2001. PMID: 11114394

9

Pharmacological manipulation of mGlu2 receptors influences cognitive performance in the rodent.

Higgins GA, Ballard TM, Kew JN, Richards JG, Kemp JA, Adam G, Woltering T, Nakanishi S, Mutel V. Higgins GA, et al. Among authors: adam g. Neuropharmacology. 2004 Jun;46(7):907-17. doi: 10.1016/j.neuropharm.2004.01.018. Neuropharmacology. 2004. PMID: 15081787

10

Novel hexahydrospiro[piperidine-4,1'-pyrrolo[3,4-c]pyrroles]: highly selective small-molecule nociceptin/orphanin FQ receptor agonists.

Kolczewski S, Adam G, Cesura AM, Jenck F, Hennig M, Oberhauser T, Poli SM, Rössler F, Röver S, Wichmann J, Dautzenberg FM. Kolczewski S, et al. Among authors: adam g. J Med Chem. 2003 Jan 16;46(2):255-64. doi: 10.1021/jm0209174. J Med Chem. 2003. PMID: 12519064

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