Gatti S - Search Results

1

Synthesis and characterization of 8-ethynyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: new potent non-competitive metabotropic glutamate receptor 2/3 antagonists. Part 1.

Woltering TJ, Adam G, Alanine A, Wichmann J, Knoflach F, Mutel V, Gatti S. Woltering TJ, et al. Among authors: gatti s. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6811-5. doi: 10.1016/j.bmcl.2007.10.026. Epub 2007 Oct 17. Bioorg Med Chem Lett. 2007. PMID: 17964783

2

Structural determinants of allosteric antagonism at metabotropic glutamate receptor 2: mechanistic studies with new potent negative allosteric modulators.

Lundström L, Bissantz C, Beck J, Wettstein JG, Woltering TJ, Wichmann J, Gatti S. Lundström L, et al. Among authors: gatti s. Br J Pharmacol. 2011 Sep;164(2b):521-37. doi: 10.1111/j.1476-5381.2011.01409.x. Br J Pharmacol. 2011. PMID: 21470207 Free PMC article.

3

Pharmacological and molecular characterization of the positive allosteric modulators of metabotropic glutamate receptor 2.

Lundström L, Bissantz C, Beck J, Dellenbach M, Woltering TJ, Wichmann J, Gatti S. Lundström L, et al. Among authors: gatti s. Neuropharmacology. 2016 Dec;111:253-265. doi: 10.1016/j.neuropharm.2016.08.032. Epub 2016 Aug 30. Neuropharmacology. 2016. PMID: 27590915 Review.

4

Reprint of Pharmacological and molecular characterization of the positive allosteric modulators of metabotropic glutamate receptor 2.

Lundström L, Bissantz C, Beck J, Dellenbach M, Woltering TJ, Wichmann J, Gatti S. Lundström L, et al. Among authors: gatti s. Neuropharmacology. 2017 Mar 15;115:115-127. doi: 10.1016/j.neuropharm.2016.08.040. Epub 2017 Feb 16. Neuropharmacology. 2017. PMID: 28216000 Review.

5

Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 4. In vivo active potent and selective non-competitive metabotropic glutamate receptor 2/3 antagonists.

Woltering TJ, Wichmann J, Goetschi E, Knoflach F, Ballard TM, Huwyler J, Gatti S. Woltering TJ, et al. Among authors: gatti s. Bioorg Med Chem Lett. 2010 Dec 1;20(23):6969-74. doi: 10.1016/j.bmcl.2010.09.125. Epub 2010 Oct 21. Bioorg Med Chem Lett. 2010. PMID: 20971004

6

Asymmetric synthesis and receptor pharmacology of the group II mGlu receptor ligand (1S,2R,3R,5R,6S)-2-amino-3-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid-HYDIA.

Woltering TJ, Adam G, Huguenin P, Wichmann J, Kolczewski S, Gatti S, Bourson A, Kew JN, Richards G, Kemp JA, Mutel V, Knoflach F. Woltering TJ, et al. Among authors: gatti s. ChemMedChem. 2008 Feb;3(2):323-35. doi: 10.1002/cmdc.200700226. ChemMedChem. 2008. PMID: 18058780

7

Synthesis and characterization of 8-ethynyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: part 2. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists.

Woltering TJ, Adam G, Wichmann J, Goetschi E, Kew JN, Knoflach F, Mutel V, Gatti S. Woltering TJ, et al. Among authors: gatti s. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1091-5. doi: 10.1016/j.bmcl.2007.12.005. Epub 2007 Dec 8. Bioorg Med Chem Lett. 2008. PMID: 18096387

8

Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 3. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists.

Woltering TJ, Wichmann J, Goetschi E, Adam G, Kew JN, Knoflach F, Ballard TM, Huwyler J, Mutel V, Gatti S. Woltering TJ, et al. Among authors: gatti s. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2725-9. doi: 10.1016/j.bmcl.2008.02.076. Epub 2008 Mar 5. Bioorg Med Chem Lett. 2008. PMID: 18374569

9

Mutagenesis and molecular modeling of the orthosteric binding site of the mGlu2 receptor determining interactions of the group II receptor antagonist (3)H-HYDIA.

Lundström L, Kuhn B, Beck J, Borroni E, Wettstein JG, Woltering TJ, Gatti S. Lundström L, et al. Among authors: gatti s. ChemMedChem. 2009 Jul;4(7):1086-94. doi: 10.1002/cmdc.200900028. ChemMedChem. 2009. PMID: 19402024

10

Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity.

Porter RH, Jaeschke G, Spooren W, Ballard TM, Büttelmann B, Kolczewski S, Peters JU, Prinssen E, Wichmann J, Vieira E, Mühlemann A, Gatti S, Mutel V, Malherbe P. Porter RH, et al. Among authors: gatti s. J Pharmacol Exp Ther. 2005 Nov;315(2):711-21. doi: 10.1124/jpet.105.089839. Epub 2005 Jul 22. J Pharmacol Exp Ther. 2005. PMID: 16040814

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