Ku70 is required for late B cell development and immunoglobulin heavy chain class switching.
Manis JP, Gu Y, Lansford R, Sonoda E, Ferrini R, Davidson L, Rajewsky K, Alt FW.
Manis JP, et al.
J Exp Med. 1998 Jun 15;187(12):2081-9. doi: 10.1084/jem.187.12.2081.
J Exp Med. 1998.
PMID: 9625768
Free PMC article.
Ku70 and Ku80 form a DNA end-binding complex required for DNA double strand break repair and V(D)J recombination. Ku70(-/-) (K70T) mice, like recombination activating gene (RAG)-1- or RAG-2-deficient (R1T or R2T) mice, have impaired B and T cell development at an early pro …
Ku70 and Ku80 form a DNA end-binding complex required for DNA double strand break repair and V(D)J recombination. Ku70(-/-) (K70T) mi …