Hoylaerts MF - Search Results

1

Increased Gs signalling in platelets and impaired collagen activation, due to a defect in the dystrophin gene, result in increased blood loss during spinal surgery.

Labarque V, Freson K, Thys C, Wittevrongel C, Hoylaerts MF, De Vos R, Goemans N, Van Geet C. Labarque V, et al. Among authors: hoylaerts mf. Hum Mol Genet. 2008 Feb 1;17(3):357-66. doi: 10.1093/hmg/ddm312. Epub 2007 Nov 1. Hum Mol Genet. 2008. PMID: 17981813

2

Different substitutions at residue D218 of the X-linked transcription factor GATA1 lead to altered clinical severity of macrothrombocytopenia and anemia and are associated with variable skewed X inactivation.

Freson K, Matthijs G, Thys C, Mariën P, Hoylaerts MF, Vermylen J, Van Geet C. Freson K, et al. Among authors: hoylaerts mf. Hum Mol Genet. 2002 Jan 15;11(2):147-52. doi: 10.1093/hmg/11.2.147. Hum Mol Genet. 2002. PMID: 11809723 Free article.

3

Pseudohypoparathyroidism type Ib with disturbed imprinting in the GNAS1 cluster and Gsalpha deficiency in platelets.

Freson K, Thys C, Wittevrongel C, Proesmans W, Hoylaerts MF, Vermylen J, Van Geet C. Freson K, et al. Among authors: hoylaerts mf. Hum Mol Genet. 2002 Oct 15;11(22):2741-50. doi: 10.1093/hmg/11.22.2741. Hum Mol Genet. 2002. PMID: 12374764

4

Molecular cloning and characterization of the GATA1 cofactor human FOG1 and assessment of its binding to GATA1 proteins carrying D218 substitutions.

Freson K, Thys C, Wittewrongel C, Vermylen J, Hoylaerts MF, Van Geet C. Freson K, et al. Among authors: hoylaerts mf. Hum Genet. 2003 Jan;112(1):42-9. doi: 10.1007/s00439-002-0832-1. Epub 2002 Oct 16. Hum Genet. 2003. PMID: 12483298

5

Functional polymorphisms in the paternally expressed XLalphas and its cofactor ALEX decrease their mutual interaction and enhance receptor-mediated cAMP formation.

Freson K, Jaeken J, Van Helvoirt M, de Zegher F, Wittevrongel C, Thys C, Hoylaerts MF, Vermylen J, Van Geet C. Freson K, et al. Among authors: hoylaerts mf. Hum Mol Genet. 2003 May 15;12(10):1121-30. doi: 10.1093/hmg/ddg130. Hum Mol Genet. 2003. PMID: 12719376

6

The pituitary adenylate cyclase-activating polypeptide is a physiological inhibitor of platelet activation.

Freson K, Hashimoto H, Thys C, Wittevrongel C, Danloy S, Morita Y, Shintani N, Tomiyama Y, Vermylen J, Hoylaerts MF, Baba A, Van Geet C. Freson K, et al. Among authors: hoylaerts mf. J Clin Invest. 2004 Mar;113(6):905-12. doi: 10.1172/JCI19252. J Clin Invest. 2004. PMID: 15067323 Free PMC article.

7

PACAP and its receptor VPAC1 regulate megakaryocyte maturation: therapeutic implications.

Freson K, Peeters K, De Vos R, Wittevrongel C, Thys C, Hoylaerts MF, Vermylen J, Van Geet C. Freson K, et al. Among authors: hoylaerts mf. Blood. 2008 Feb 15;111(4):1885-93. doi: 10.1182/blood-2007-06-098558. Epub 2007 Nov 13. Blood. 2008. PMID: 18000164 Free article.

8

Recurrent arterial thrombosis linked to autoimmune antibodies enhancing von Willebrand factor binding to platelets and inducing Fc gamma RII receptor-mediated platelet activation.

Hoylaerts MF, Thys C, Arnout J, Vermylen J. Hoylaerts MF, et al. Blood. 1998 Apr 15;91(8):2810-7. Blood. 1998. PMID: 9531591 Free article.

9

Platelet characteristics in patients with X-linked macrothrombocytopenia because of a novel GATA1 mutation.

Freson K, Devriendt K, Matthijs G, Van Hoof A, De Vos R, Thys C, Minner K, Hoylaerts MF, Vermylen J, Van Geet C. Freson K, et al. Among authors: hoylaerts mf. Blood. 2001 Jul 1;98(1):85-92. doi: 10.1182/blood.v98.1.85. Blood. 2001. PMID: 11418466 Free article.

10

Genetic variation of the extra-large stimulatory G protein alpha-subunit leads to Gs hyperfunction in platelets and is a risk factor for bleeding.

Freson K, Hoylaerts MF, Jaeken J, Eyssen M, Arnout J, Vermylen J, Van Geet C. Freson K, et al. Among authors: hoylaerts mf. Thromb Haemost. 2001 Sep;86(3):733-8. Thromb Haemost. 2001. PMID: 11583302

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