Garrett MD - Search Results

1

CHK2 kinase: cancer susceptibility and cancer therapy - two sides of the same coin?

Antoni L, Sodha N, Collins I, Garrett MD. Antoni L, et al. Among authors: garrett md. Nat Rev Cancer. 2007 Dec;7(12):925-36. doi: 10.1038/nrc2251. Nat Rev Cancer. 2007. PMID: 18004398 Review.

2

Rare germ line CHEK2 variants identified in breast cancer families encode proteins that show impaired activation.

Sodha N, Mantoni TS, Tavtigian SV, Eeles R, Garrett MD. Sodha N, et al. Among authors: garrett md. Cancer Res. 2006 Sep 15;66(18):8966-70. doi: 10.1158/0008-5472.CAN-06-1990. Cancer Res. 2006. PMID: 16982735

3

CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors.

Anderson VE, Walton MI, Eve PD, Boxall KJ, Antoni L, Caldwell JJ, Aherne W, Pearl LH, Oliver AW, Collins I, Garrett MD. Anderson VE, et al. Among authors: garrett md. Cancer Res. 2011 Jan 15;71(2):463-72. doi: 10.1158/0008-5472.CAN-10-1252. Cancer Res. 2011. PMID: 21239475 Free PMC article.

4

Anticancer therapy with checkpoint inhibitors: what, where and when?

Garrett MD, Collins I. Garrett MD, et al. Trends Pharmacol Sci. 2011 May;32(5):308-16. doi: 10.1016/j.tips.2011.02.014. Epub 2011 Mar 30. Trends Pharmacol Sci. 2011. PMID: 21458083 Review.

5

Targeting the cell division cycle in cancer: CDK and cell cycle checkpoint kinase inhibitors.

Collins I, Garrett MD. Collins I, et al. Among authors: garrett md. Curr Opin Pharmacol. 2005 Aug;5(4):366-73. doi: 10.1016/j.coph.2005.04.009. Curr Opin Pharmacol. 2005. PMID: 15964238 Review.

6

Identification of inhibitors of checkpoint kinase 1 through template screening.

Matthews TP, Klair S, Burns S, Boxall K, Cherry M, Fisher M, Westwood IM, Walton MI, McHardy T, Cheung KM, Van Montfort R, Williams D, Aherne GW, Garrett MD, Reader J, Collins I. Matthews TP, et al. Among authors: garrett md. J Med Chem. 2009 Aug 13;52(15):4810-9. doi: 10.1021/jm900314j. J Med Chem. 2009. PMID: 19572549

7

Identification and characterisation of 2-aminopyridine inhibitors of checkpoint kinase 2.

Hilton S, Naud S, Caldwell JJ, Boxall K, Burns S, Anderson VE, Antoni L, Allen CE, Pearl LH, Oliver AW, Wynne Aherne G, Garrett MD, Collins I. Hilton S, et al. Among authors: garrett md. Bioorg Med Chem. 2010 Jan 15;18(2):707-18. doi: 10.1016/j.bmc.2009.11.058. Epub 2009 Dec 6. Bioorg Med Chem. 2010. PMID: 20022510

8

The preclinical pharmacology and therapeutic activity of the novel CHK1 inhibitor SAR-020106.

Walton MI, Eve PD, Hayes A, Valenti M, De Haven Brandon A, Box G, Boxall KJ, Aherne GW, Eccles SA, Raynaud FI, Williams DH, Reader JC, Collins I, Garrett MD. Walton MI, et al. Among authors: garrett md. Mol Cancer Ther. 2010 Jan;9(1):89-100. doi: 10.1158/1535-7163.MCT-09-0938. Epub 2010 Jan 6. Mol Cancer Ther. 2010. PMID: 20053762 Free article.

9

Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2.

Caldwell JJ, Welsh EJ, Matijssen C, Anderson VE, Antoni L, Boxall K, Urban F, Hayes A, Raynaud FI, Rigoreau LJ, Raynham T, Aherne GW, Pearl LH, Oliver AW, Garrett MD, Collins I. Caldwell JJ, et al. Among authors: garrett md. J Med Chem. 2011 Jan 27;54(2):580-90. doi: 10.1021/jm101150b. Epub 2010 Dec 27. J Med Chem. 2011. PMID: 21186793

10

Discovery of 3-alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles as selective, orally bioavailable CHK1 inhibitors.

Lainchbury M, Matthews TP, McHardy T, Boxall KJ, Walton MI, Eve PD, Hayes A, Valenti MR, de Haven Brandon AK, Box G, Aherne GW, Reader JC, Raynaud FI, Eccles SA, Garrett MD, Collins I. Lainchbury M, et al. Among authors: garrett md. J Med Chem. 2012 Nov 26;55(22):10229-40. doi: 10.1021/jm3012933. Epub 2012 Oct 19. J Med Chem. 2012. PMID: 23082860 Free PMC article.

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