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Integrin alpha2beta1 is the required receptor for endorepellin angiostatic activity.
J Biol Chem. 2008 Jan 25;283(4):2335-43. doi: 10.1074/jbc.M708364200. Epub 2007 Nov 15.
J Biol Chem. 2008.
PMID: 18024432
Free article.
Endorepellin in vivo: targeting the tumor vasculature and retarding cancer growth and metabolism.
Bix G, Castello R, Burrows M, Zoeller JJ, Weech M, Iozzo RA, Cardi C, Thakur ML, Barker CA, Camphausen K, Iozzo RV.
Bix G, et al. Among authors: iozzo ra.
J Natl Cancer Inst. 2006 Nov 15;98(22):1634-46. doi: 10.1093/jnci/djj441.
J Natl Cancer Inst. 2006.
PMID: 17105986
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Endorepellin, the C-terminal angiostatic module of perlecan, enhances collagen-platelet responses via the alpha2beta1-integrin receptor.
Bix G, Iozzo RA, Woodall B, Burrows M, McQuillan A, Campbell S, Fields GB, Iozzo RV.
Bix G, et al. Among authors: iozzo ra.
Blood. 2007 May 1;109(9):3745-8. doi: 10.1182/blood-2006-08-039925. Epub 2006 Dec 29.
Blood. 2007.
PMID: 17197432
Free PMC article.
Clinical Trial.
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A soluble ectodomain of LRIG1 inhibits cancer cell growth by attenuating basal and ligand-dependent EGFR activity.
Goldoni S, Iozzo RA, Kay P, Campbell S, McQuillan A, Agnew C, Zhu JX, Keene DR, Reed CC, Iozzo RV.
Goldoni S, et al. Among authors: iozzo ra.
Oncogene. 2007 Jan 18;26(3):368-81. doi: 10.1038/sj.onc.1209803. Epub 2006 Jul 17.
Oncogene. 2007.
PMID: 16847455
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