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Page 1
Structure and property based design of factor Xa inhibitors: biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs.
Young RJ, Borthwick AD, Brown D, Burns-Kurtis CL, Campbell M, Chan C, Charbaut M, Convery MA, Diallo H, Hortense E, Irving WR, Kelly HA, King NP, Kleanthous S, Mason AM, Pateman AJ, Patikis AN, Pinto IL, Pollard DR, Senger S, Shah GP, Toomey JR, Watson NS, Weston HE, Zhou P. Young RJ, et al. Among authors: king np. Bioorg Med Chem Lett. 2008 Jan 1;18(1):28-33. doi: 10.1016/j.bmcl.2007.11.019. Epub 2007 Nov 13. Bioorg Med Chem Lett. 2008. PMID: 18053714
Design and synthesis of orally active pyrrolidin-2-one-based factor Xa inhibitors.
Watson NS, Brown D, Campbell M, Chan C, Chaudry L, Convery MA, Fenwick R, Hamblin JN, Haslam C, Kelly HA, King NP, Kurtis CL, Leach AR, Manchee GR, Mason AM, Mitchell C, Patel C, Patel VK, Senger S, Shah GP, Weston HE, Whitworth C, Young RJ. Watson NS, et al. Among authors: king np. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3784-8. doi: 10.1016/j.bmcl.2006.04.053. Epub 2006 May 11. Bioorg Med Chem Lett. 2006. PMID: 16697194
Structure- and property-based design of factor Xa inhibitors: pyrrolidin-2-ones with acyclic alanyl amides as P4 motifs.
Young RJ, Campbell M, Borthwick AD, Brown D, Burns-Kurtis CL, Chan C, Convery MA, Crowe MC, Dayal S, Diallo H, Kelly HA, King NP, Kleanthous S, Mason AM, Mordaunt JE, Patel C, Pateman AJ, Senger S, Shah GP, Smith PW, Watson NS, Weston HE, Zhou P. Young RJ, et al. Among authors: king np. Bioorg Med Chem Lett. 2006 Dec 1;16(23):5953-7. doi: 10.1016/j.bmcl.2006.09.001. Epub 2006 Sep 18. Bioorg Med Chem Lett. 2006. PMID: 16982190
Aryl sulphonyl amides as potent agonists of the growth hormone secretagogue (ghrelin) receptor.
Witherington J, Abberley L, Bellenie BR, Boatman R, Collis K, Dean DK, Gaiba A, King NP, Shuker N, Steadman JG, Takle AK, Sanger G, Butler S, McKay F, Muir A, Winborn K, Ward RW, Heightman TD. Witherington J, et al. Among authors: king np. Bioorg Med Chem Lett. 2009 Feb 1;19(3):684-7. doi: 10.1016/j.bmcl.2008.12.042. Epub 2008 Dec 14. Bioorg Med Chem Lett. 2009. PMID: 19128969
Potent achiral agonists of the growth hormone secretagogue (ghrelin) receptor. Part 2: Lead optimisation.
Witherington J, Abberley L, Briggs MA, Collis K, Dean DK, Gaiba A, King NP, Kraus H, Shuker N, Steadman JG, Takle AK, Sanger G, Wadsworth G, Butler S, McKay F, Muir A, Winborn K, Heightman TD. Witherington J, et al. Among authors: king np. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2203-5. doi: 10.1016/j.bmcl.2007.12.021. Epub 2007 Dec 15. Bioorg Med Chem Lett. 2008. PMID: 18316188
Deep mutational scanning of H5 hemagglutinin to inform influenza virus surveillance.
Dadonaite B, Ahn JJ, Ort JT, Yu J, Furey C, Dosey A, Hannon WW, Vincent Baker AL, Webby RJ, King NP, Liu Y, Hensley SE, Peacock TP, Moncla LH, Bloom JD. Dadonaite B, et al. Among authors: king np. PLoS Biol. 2024 Nov 12;22(11):e3002916. doi: 10.1371/journal.pbio.3002916. eCollection 2024 Nov. PLoS Biol. 2024. PMID: 39531474 Free PMC article.
Computational design of bifaceted protein nanomaterials with tailorable properties.
Rankovic S, Carr KD, Decarreau J, Skotheim R, Kibler RD, Ols S, Lee S, Chun J, Tooley M, Dauparas J, Eisenach HE, Glögl M, Weidle C, Borst AJ, Baker D, King NP. Rankovic S, et al. Among authors: king np. bioRxiv [Preprint]. 2024 Oct 22:2024.10.18.619149. doi: 10.1101/2024.10.18.619149. bioRxiv. 2024. PMID: 39484564 Free PMC article. Preprint.
Potent neutralization of SARS-CoV-2 variants by RBD nanoparticle and prefusion-stabilized spike immunogens.
Miranda MC, Kepl E, Navarro MJ, Chen C, Johnson M, Sprouse KR, Stewart C, Palser A, Valdez A, Pettie D, Sydeman C, Ogohara C, Kraft JC, Pham M, Murphy M, Wrenn S, Fiala B, Ravichandran R, Ellis D, Carter L, Corti D, Kellam P, Lee K, Walls AC, Veesler D, King NP. Miranda MC, et al. Among authors: king np. NPJ Vaccines. 2024 Oct 8;9(1):184. doi: 10.1038/s41541-024-00982-1. NPJ Vaccines. 2024. PMID: 39379400 Free PMC article.
138 results