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The human combinatorial antibody library HuCAL GOLD combines diversification of all six CDRs according to the natural immune system with a novel display method for efficient selection of high-affinity antibodies.
Rothe C, Urlinger S, Löhning C, Prassler J, Stark Y, Jäger U, Hubner B, Bardroff M, Pradel I, Boss M, Bittlingmaier R, Bataa T, Frisch C, Brocks B, Honegger A, Urban M. Rothe C, et al. Among authors: bittlingmaier r. J Mol Biol. 2008 Feb 29;376(4):1182-200. doi: 10.1016/j.jmb.2007.12.018. Epub 2007 Dec 15. J Mol Biol. 2008. PMID: 18191144