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The human combinatorial antibody library HuCAL GOLD combines diversification of all six CDRs according to the natural immune system with a novel display method for efficient selection of high-affinity antibodies.
Rothe C, Urlinger S, Löhning C, Prassler J, Stark Y, Jäger U, Hubner B, Bardroff M, Pradel I, Boss M, Bittlingmaier R, Bataa T, Frisch C, Brocks B, Honegger A, Urban M. Rothe C, et al. Among authors: urlinger s. J Mol Biol. 2008 Feb 29;376(4):1182-200. doi: 10.1016/j.jmb.2007.12.018. Epub 2007 Dec 15. J Mol Biol. 2008. PMID: 18191144
A fully synthetic human Fab antibody library based on fixed VH/VL framework pairings with favorable biophysical properties.
Tiller T, Schuster I, Deppe D, Siegers K, Strohner R, Herrmann T, Berenguer M, Poujol D, Stehle J, Stark Y, Heßling M, Daubert D, Felderer K, Kaden S, Kölln J, Enzelberger M, Urlinger S. Tiller T, et al. Among authors: urlinger s. MAbs. 2013 May-Jun;5(3):445-70. doi: 10.4161/mabs.24218. Epub 2013 Apr 9. MAbs. 2013. PMID: 23571156 Free PMC article.
Crystallization and molecular-replacement solution of a diagnostic fluorescent dye in complex with a specific Fab fragment.
Hillig RC, Baesler S, Urlinger S, Stark Y, Bauer S, Badock V, Huber M, Bahr I, Schirner M, Licha K. Hillig RC, et al. Among authors: urlinger s. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Mar 1;63(Pt 3):217-23. doi: 10.1107/S1744309107005957. Epub 2007 Feb 23. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007. PMID: 17329818 Free PMC article.
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