Cai Z - Search Results

1

Solubilizing mutations used to crystallize one CFTR domain attenuate the trafficking and channel defects caused by the major cystic fibrosis mutation.

Pissarra LS, Farinha CM, Xu Z, Schmidt A, Thibodeau PH, Cai Z, Thomas PJ, Sheppard DN, Amaral MD. Pissarra LS, et al. Among authors: cai z. Chem Biol. 2008 Jan;15(1):62-9. doi: 10.1016/j.chembiol.2007.11.012. Chem Biol. 2008. PMID: 18215773

2

Phloxine B interacts with the cystic fibrosis transmembrane conductance regulator at multiple sites to modulate channel activity.

Cai Z, Sheppard DN. Cai Z, et al. J Biol Chem. 2002 May 31;277(22):19546-53. doi: 10.1074/jbc.M108023200. Epub 2002 Mar 19. J Biol Chem. 2002. PMID: 11904291 Free article.

3

Differential sensitivity of the cystic fibrosis (CF)-associated mutants G551D and G1349D to potentiators of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel.

Cai Z, Taddei A, Sheppard DN. Cai Z, et al. J Biol Chem. 2006 Jan 27;281(4):1970-7. doi: 10.1074/jbc.M510576200. Epub 2005 Nov 25. J Biol Chem. 2006. PMID: 16311240 Free article.

4

Revertant mutants G550E and 4RK rescue cystic fibrosis mutants in the first nucleotide-binding domain of CFTR by different mechanisms.

Roxo-Rosa M, Xu Z, Schmidt A, Neto M, Cai Z, Soares CM, Sheppard DN, Amaral MD. Roxo-Rosa M, et al. Among authors: cai z. Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17891-6. doi: 10.1073/pnas.0608312103. Epub 2006 Nov 10. Proc Natl Acad Sci U S A. 2006. PMID: 17098864 Free PMC article.

5

Direct sensing of intracellular pH by the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel.

Chen JH, Cai Z, Sheppard DN. Chen JH, et al. Among authors: cai z. J Biol Chem. 2009 Dec 18;284(51):35495-506. doi: 10.1074/jbc.M109.072678. J Biol Chem. 2009. PMID: 19837660 Free PMC article.

6

Understanding how cystic fibrosis mutations disrupt CFTR function: from single molecules to animal models.

Wang Y, Wrennall JA, Cai Z, Li H, Sheppard DN. Wang Y, et al. Among authors: cai z. Int J Biochem Cell Biol. 2014 Jul;52:47-57. doi: 10.1016/j.biocel.2014.04.001. Epub 2014 Apr 13. Int J Biochem Cell Biol. 2014. PMID: 24727426 Review.

7

Partial rescue of F508del-cystic fibrosis transmembrane conductance regulator channel gating with modest improvement of protein processing, but not stability, by a dual-acting small molecule.

Liu J, Bihler H, Farinha CM, Awatade NT, Romão AM, Mercadante D, Cheng Y, Musisi I, Jantarajit W, Wang Y, Cai Z, Amaral MD, Mense M, Sheppard DN. Liu J, et al. Among authors: cai z. Br J Pharmacol. 2018 Apr;175(7):1017-1038. doi: 10.1111/bph.14141. Epub 2018 Feb 22. Br J Pharmacol. 2018. PMID: 29318594 Free PMC article.

8

Prolonged treatment of cells with genistein modulates the expression and function of the cystic fibrosis transmembrane conductance regulator.

Schmidt A, Hughes LK, Cai Z, Mendes F, Li H, Sheppard DN, Amaral MD. Schmidt A, et al. Among authors: cai z. Br J Pharmacol. 2008 Mar;153(6):1311-23. doi: 10.1038/sj.bjp.0707663. Epub 2008 Jan 28. Br J Pharmacol. 2008. PMID: 18223673 Free PMC article.

9

Targeting F508del-CFTR to develop rational new therapies for cystic fibrosis.

Cai ZW, Liu J, Li HY, Sheppard DN. Cai ZW, et al. Acta Pharmacol Sin. 2011 Jun;32(6):693-701. doi: 10.1038/aps.2011.71. Acta Pharmacol Sin. 2011. PMID: 21642944 Free PMC article. Review.

10

Voltage-dependent gating of the cystic fibrosis transmembrane conductance regulator Cl- channel.

Cai Z, Scott-Ward TS, Sheppard DN. Cai Z, et al. J Gen Physiol. 2003 Nov;122(5):605-20. doi: 10.1085/jgp.200308921. J Gen Physiol. 2003. PMID: 14581585 Free PMC article.

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