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WHIM syndromes with different genetic anomalies are accounted for by impaired CXCR4 desensitization to CXCL12.
Balabanian K, Lagane B, Pablos JL, Laurent L, Planchenault T, Verola O, Lebbe C, Kerob D, Dupuy A, Hermine O, Nicolas JF, Latger-Cannard V, Bensoussan D, Bordigoni P, Baleux F, Le Deist F, Virelizier JL, Arenzana-Seisdedos F, Bachelerie F. Balabanian K, et al. Blood. 2005 Mar 15;105(6):2449-57. doi: 10.1182/blood-2004-06-2289. Epub 2004 Nov 9. Blood. 2005. PMID: 15536153 Free article.
Small neutralizing molecules to inhibit actions of the chemokine CXCL12.
Hachet-Haas M, Balabanian K, Rohmer F, Pons F, Franchet C, Lecat S, Chow KY, Dagher R, Gizzi P, Didier B, Lagane B, Kellenberger E, Bonnet D, Baleux F, Haiech J, Parmentier M, Frossard N, Arenzana-Seisdedos F, Hibert M, Galzi JL. Hachet-Haas M, et al. J Biol Chem. 2008 Aug 22;283(34):23189-99. doi: 10.1074/jbc.M803947200. Epub 2008 Jun 13. J Biol Chem. 2008. PMID: 18556651 Free article.
Leukocyte elastase negatively regulates Stromal cell-derived factor-1 (SDF-1)/CXCR4 binding and functions by amino-terminal processing of SDF-1 and CXCR4.
Valenzuela-Fernández A, Planchenault T, Baleux F, Staropoli I, Le-Barillec K, Leduc D, Delaunay T, Lazarini F, Virelizier JL, Chignard M, Pidard D, Arenzana-Seisdedos F. Valenzuela-Fernández A, et al. J Biol Chem. 2002 May 3;277(18):15677-89. doi: 10.1074/jbc.M111388200. Epub 2002 Feb 26. J Biol Chem. 2002. PMID: 11867624 Free article.
142 results