Hendriks BS - Search Results

1

Multiple effects of acetaminophen and p38 inhibitors: towards pathway toxicology.

Xu JJ, Hendriks BS, Zhao J, de Graaf D. Xu JJ, et al. Among authors: hendriks bs. FEBS Lett. 2008 Apr 9;582(8):1276-82. doi: 10.1016/j.febslet.2008.01.063. Epub 2008 Feb 20. FEBS Lett. 2008. PMID: 18282474 Free article. Review.

2

Elevated GM-CSF and IL-1beta levels compromise the ability of p38 MAPK inhibitors to modulate TNFalpha levels in the human monocytic/macrophage U937 cell line.

Espelin CW, Goldsipe A, Sorger PK, Lauffenburger DA, de Graaf D, Hendriks BS. Espelin CW, et al. Among authors: hendriks bs. Mol Biosyst. 2010 Oct;6(10):1956-72. doi: 10.1039/c002848g. Epub 2010 Jul 9. Mol Biosyst. 2010. PMID: 20617251

3

Applying computational modeling to drug discovery and development.

Kumar N, Hendriks BS, Janes KA, de Graaf D, Lauffenburger DA. Kumar N, et al. Among authors: hendriks bs. Drug Discov Today. 2006 Sep;11(17-18):806-11. doi: 10.1016/j.drudis.2006.07.010. Drug Discov Today. 2006. PMID: 16935748 Review.

4

Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity.

Cosgrove BD, King BM, Hasan MA, Alexopoulos LG, Farazi PA, Hendriks BS, Griffith LG, Sorger PK, Tidor B, Xu JJ, Lauffenburger DA. Cosgrove BD, et al. Among authors: hendriks bs. Toxicol Appl Pharmacol. 2009 Jun 15;237(3):317-30. doi: 10.1016/j.taap.2009.04.002. Epub 2009 Apr 9. Toxicol Appl Pharmacol. 2009. PMID: 19362101 Free PMC article.

5

Two additive mechanisms impair the differentiation of 'substrate-selective' p38 inhibitors from classical p38 inhibitors in vitro.

Hendriks BS, Seidl KM, Chabot JR. Hendriks BS, et al. BMC Syst Biol. 2010 Mar 15;4:23. doi: 10.1186/1752-0509-4-23. BMC Syst Biol. 2010. PMID: 20230629 Free PMC article.

6

Analysis of mechanistic pathway models in drug discovery: p38 pathway.

Hendriks BS, Hua F, Chabot JR. Hendriks BS, et al. Biotechnol Prog. 2008 Jan-Feb;24(1):96-109. doi: 10.1021/bp070084g. Epub 2007 Oct 5. Biotechnol Prog. 2008. PMID: 17918858

7

Computational modelling of ErbB family phosphorylation dynamics in response to transforming growth factor alpha and heregulin indicates spatial compartmentation of phosphatase activity.

Hendriks BS, Cook J, Burke JM, Beusmans JM, Lauffenburger DA, de Graaf D. Hendriks BS, et al. Syst Biol (Stevenage). 2006 Jan;153(1):22-33. doi: 10.1049/ip-syb:20050057. Syst Biol (Stevenage). 2006. PMID: 16983832

8

Decreased internalisation of erbB1 mutants in lung cancer is linked with a mechanism conferring sensitivity to gefitinib.

Hendriks BS, Griffiths GJ, Benson R, Kenyon D, Lazzara M, Swinton J, Beck S, Hickinson M, Beusmans JM, Lauffenburger D, de Graaf D. Hendriks BS, et al. Syst Biol (Stevenage). 2006 Nov;153(6):457-66. doi: 10.1049/ip-syb:20050108. Syst Biol (Stevenage). 2006. PMID: 17186707

9

Cytokine-associated drug toxicity in human hepatocytes is associated with signaling network dysregulation.

Cosgrove BD, Alexopoulos LG, Hang TC, Hendriks BS, Sorger PK, Griffith LG, Lauffenburger DA. Cosgrove BD, et al. Among authors: hendriks bs. Mol Biosyst. 2010 Jul;6(7):1195-206. doi: 10.1039/b926287c. Epub 2010 Apr 1. Mol Biosyst. 2010. PMID: 20361094 Free PMC article.

10

Functional pathway pharmacology: chemical tools, pathway knowledge and mechanistic model-based interpretation of experimental data.

Hendriks BS. Hendriks BS. Curr Opin Chem Biol. 2010 Aug;14(4):489-97. doi: 10.1016/j.cbpa.2010.06.167. Epub 2010 Jul 6. Curr Opin Chem Biol. 2010. PMID: 20609614 Review.

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