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Hepatic overexpression of hormone-sensitive lipase and adipose triglyceride lipase promotes fatty acid oxidation, stimulates direct release of free fatty acids, and ameliorates steatosis.
Reid BN, Ables GP, Otlivanchik OA, Schoiswohl G, Zechner R, Blaner WS, Goldberg IJ, Schwabe RF, Chua SC Jr, Huang LS. Reid BN, et al. Among authors: schwabe rf. J Biol Chem. 2008 May 9;283(19):13087-99. doi: 10.1074/jbc.M800533200. Epub 2008 Mar 12. J Biol Chem. 2008. PMID: 18337240 Free PMC article.
Hepatic stellate cell lipid droplets: a specialized lipid droplet for retinoid storage.
Blaner WS, O'Byrne SM, Wongsiriroj N, Kluwe J, D'Ambrosio DM, Jiang H, Schwabe RF, Hillman EM, Piantedosi R, Libien J. Blaner WS, et al. Among authors: schwabe rf. Biochim Biophys Acta. 2009 Jun;1791(6):467-73. doi: 10.1016/j.bbalip.2008.11.001. Epub 2008 Nov 24. Biochim Biophys Acta. 2009. PMID: 19071229 Free PMC article. Review.
Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis.
Cai B, Dongiovanni P, Corey KE, Wang X, Shmarakov IO, Zheng Z, Kasikara C, Davra V, Meroni M, Chung RT, Rothlin CV, Schwabe RF, Blaner WS, Birge RB, Valenti L, Tabas I. Cai B, et al. Among authors: schwabe rf. Cell Metab. 2020 Feb 4;31(2):406-421.e7. doi: 10.1016/j.cmet.2019.11.013. Epub 2019 Dec 12. Cell Metab. 2020. PMID: 31839486 Free PMC article.
Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis.
Li Y, Schwabe RF, DeVries-Seimon T, Yao PM, Gerbod-Giannone MC, Tall AR, Davis RJ, Flavell R, Brenner DA, Tabas I. Li Y, et al. Among authors: schwabe rf. J Biol Chem. 2005 Jun 10;280(23):21763-72. doi: 10.1074/jbc.M501759200. Epub 2005 Apr 11. J Biol Chem. 2005. PMID: 15826936 Free article.
TLR4 enhances TGF-beta signaling and hepatic fibrosis.
Seki E, De Minicis S, Osterreicher CH, Kluwe J, Osawa Y, Brenner DA, Schwabe RF. Seki E, et al. Among authors: schwabe rf. Nat Med. 2007 Nov;13(11):1324-32. doi: 10.1038/nm1663. Epub 2007 Oct 21. Nat Med. 2007. PMID: 17952090
174 results