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Soluble guanylate cyclase-alpha1 deficiency selectively inhibits the pulmonary vasodilator response to nitric oxide and increases the pulmonary vascular remodeling response to chronic hypoxia.
Vermeersch P, Buys E, Pokreisz P, Marsboom G, Ichinose F, Sips P, Pellens M, Gillijns H, Swinnen M, Graveline A, Collen D, Dewerchin M, Brouckaert P, Bloch KD, Janssens S. Vermeersch P, et al. Among authors: bloch kd. Circulation. 2007 Aug 21;116(8):936-43. doi: 10.1161/CIRCULATIONAHA.106.677245. Epub 2007 Aug 6. Circulation. 2007. PMID: 17679618
sGC(alpha)1(beta)1 attenuates cardiac dysfunction and mortality in murine inflammatory shock models.
Buys ES, Cauwels A, Raher MJ, Passeri JJ, Hobai I, Cawley SM, Rauwerdink KM, Thibault H, Sips PY, Thoonen R, Scherrer-Crosbie M, Ichinose F, Brouckaert P, Bloch KD. Buys ES, et al. Among authors: bloch kd. Am J Physiol Heart Circ Physiol. 2009 Aug;297(2):H654-63. doi: 10.1152/ajpheart.00367.2009. Epub 2009 Jun 5. Am J Physiol Heart Circ Physiol. 2009. PMID: 19502556 Free PMC article.
Genetic modifiers of hypertension in soluble guanylate cyclase α1-deficient mice.
Buys ES, Raher MJ, Kirby A, Shahid M, Baron DM, Hayton SR, Tainsh LT, Sips PY, Rauwerdink KM, Yan Q, Tainsh RE, Shakartzi HR, Stevens C, Decaluwé K, Rodrigues-Machado Mda G, Malhotra R, Van de Voorde J, Wang T, Brouckaert P, Daly MJ, Bloch KD. Buys ES, et al. Among authors: bloch kd. J Clin Invest. 2012 Jun;122(6):2316-25. doi: 10.1172/JCI60119. Epub 2012 May 8. J Clin Invest. 2012. PMID: 22565307 Free PMC article.
Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice.
Thoonen R, Cauwels A, Decaluwe K, Geschka S, Tainsh RE, Delanghe J, Hochepied T, De Cauwer L, Rogge E, Voet S, Sips P, Karas RH, Bloch KD, Vuylsteke M, Stasch JP, Van de Voorde J, Buys ES, Brouckaert P. Thoonen R, et al. Among authors: bloch kd. Nat Commun. 2015 Oct 7;6:8482. doi: 10.1038/ncomms9482. Nat Commun. 2015. PMID: 26442659 Free PMC article.
243 results