Hudkins RL - Search Results

1

TIE-2/VEGF-R2 SAR and in vitro activity of C3-acyl dihydroindazolo[5,4-a]pyrrolo[3,4-c]carbazole analogs.

Underiner TL, Ruggeri B, Aimone L, Albom M, Angeles T, Chang H, Hudkins RL, Hunter K, Josef K, Robinson C, Weinberg L, Yang S, Zulli A. Underiner TL, et al. Among authors: hudkins rl. Bioorg Med Chem Lett. 2008 Apr 1;18(7):2368-72. doi: 10.1016/j.bmcl.2008.02.069. Epub 2008 Mar 4. Bioorg Med Chem Lett. 2008. PMID: 18343109

2

A new class of potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: structure-activity relationships for a series of 9-alkoxymethyl-12-(3-hydroxypropyl)indeno[2,1-a]pyrrolo[3,4-c]carbazole-5-ones and the identification of CEP-5214 and its dimethylglycine ester prodrug clinical candidate CEP-7055.

Gingrich DE, Reddy DR, Iqbal MA, Singh J, Aimone LD, Angeles TS, Albom M, Yang S, Ator MA, Meyer SL, Robinson C, Ruggeri BA, Dionne CA, Vaught JL, Mallamo JP, Hudkins RL. Gingrich DE, et al. Among authors: hudkins rl. J Med Chem. 2003 Dec 4;46(25):5375-88. doi: 10.1021/jm0301641. J Med Chem. 2003. PMID: 14640546

3

Synthesis, modeling, and in vitro activity of (3'S)-epi-K-252a analogues. Elucidating the stereochemical requirements of the 3'-sugar alcohol on trkA tyrosine kinase activity.

Gingrich DE, Yang SX, Gessner GW, Angeles TS, Hudkins RL. Gingrich DE, et al. Among authors: hudkins rl. J Med Chem. 2005 Jun 2;48(11):3776-83. doi: 10.1021/jm040178m. J Med Chem. 2005. PMID: 15916429

4

Novel C-3 N-urea, amide, and carbamate dihydroindazolo[5,4-a]pyrrolo[3,4-c]carbazole analogs as potent TIE-2 and VEGF-R2 dual inhibitors.

Becknell NC, Zulli AL, Angeles TS, Yang S, Albom MS, Aimone LD, Robinson C, Chang H, Hudkins RL. Becknell NC, et al. Among authors: hudkins rl. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5368-72. doi: 10.1016/j.bmcl.2006.07.066. Epub 2006 Aug 4. Bioorg Med Chem Lett. 2006. PMID: 16890434

5

Synthesis and mixed lineage kinase activity of pyrrolocarbazole and isoindolone analogs of (+)K-252a.

Hudkins RL, Johnson NW, Angeles TS, Gessner GW, Mallamo JP. Hudkins RL, et al. J Med Chem. 2007 Feb 8;50(3):433-41. doi: 10.1021/jm051074u. J Med Chem. 2007. PMID: 17266195

6

Design and synthesis of dihydroindazolo[5,4-a]pyrrolo[3,4-c]carbazole oximes as potent dual inhibitors of TIE-2 and VEGF-R2 receptor tyrosine kinases.

Dandu R, Zulli AL, Bacon ER, Underiner T, Robinson C, Chang H, Miknyoczki S, Grobelny J, Ruggeri BA, Yang S, Albom MS, Angeles TS, Aimone LD, Hudkins RL. Dandu R, et al. Among authors: hudkins rl. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1916-21. doi: 10.1016/j.bmcl.2008.02.001. Epub 2008 Feb 7. Bioorg Med Chem Lett. 2008. PMID: 18308565

7

8-THP-DHI analogs as potent Type I dual TIE-2/VEGF-R2 receptor tyrosine kinase inhibitors.

Hudkins RL, Zulli AL, Underiner TL, Angeles TS, Aimone LD, Meyer SL, Pauletti D, Chang H, Fedorov EV, Almo SC, Fedorov AA, Ruggeri BA. Hudkins RL, et al. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3356-60. doi: 10.1016/j.bmcl.2010.04.021. Epub 2010 Apr 13. Bioorg Med Chem Lett. 2010. PMID: 20430619

8

Identification of pyridazin-3-one derivatives as potent, selective histamine H₃ receptor inverse agonists with robust wake activity.

Hudkins RL, Aimone LD, Bailey TR, Bendesky RJ, Dandu RR, Dunn D, Gruner JA, Josef KA, Lin YG, Lyons J, Marcy VR, Mathiasen JR, Sundar BG, Tao M, Zulli AL, Raddatz R, Bacon ER. Hudkins RL, et al. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5493-7. doi: 10.1016/j.bmcl.2011.06.108. Epub 2011 Jun 30. Bioorg Med Chem Lett. 2011. PMID: 21782432

9

Synthesis and structure-activity relationships of 4,5-fused pyridazinones as histamine H₃ receptor antagonists.

Tao M, Raddatz R, Aimone LD, Hudkins RL. Tao M, et al. Among authors: hudkins rl. Bioorg Med Chem Lett. 2011 Oct 15;21(20):6126-30. doi: 10.1016/j.bmcl.2011.08.045. Epub 2011 Aug 19. Bioorg Med Chem Lett. 2011. PMID: 21906941

10

4,5-dihydropyridazin-3-one derivatives as histamine H₃ receptor inverse agonists.

Hudkins RL, Aimone LD, Dandu RR, Dunn D, Gruner JA, Huang Z, Josef KA, Lyons JA, Mathiasen JR, Tao M, Zulli AL, Raddatz R. Hudkins RL, et al. Bioorg Med Chem Lett. 2012 Jan 1;22(1):194-8. doi: 10.1016/j.bmcl.2011.11.037. Epub 2011 Nov 16. Bioorg Med Chem Lett. 2012. PMID: 22142542

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