Dent P - Search Results

1

Transient exposure of carcinoma cells to RAS/MEK inhibitors and UCN-01 causes cell death in vitro and in vivo.

Hamed H, Hawkins W, Mitchell C, Gilfor D, Zhang G, Pei XY, Dai Y, Hagan MP, Roberts JD, Yacoub A, Grant S, Dent P. Hamed H, et al. Among authors: dent p. Mol Cancer Ther. 2008 Mar;7(3):616-29. doi: 10.1158/1535-7163.MCT-07-2376. Mol Cancer Ther. 2008. PMID: 18347148

2

Pharmocologic inhibitors of the mitogen activated protein kinase cascade have the potential to interact with ionizing radiation exposure to induce cell death in carcinoma cells by multiple mechanisms.

Qiao L, Yacoub A, McKinstry R, Park JS, Caron R, Fisher PB, Hagan MP, Grant S, Dent P. Qiao L, et al. Among authors: dent p. Cancer Biol Ther. 2002 Mar-Apr;1(2):168-76. doi: 10.4161/cbt.64. Cancer Biol Ther. 2002. PMID: 12170777 Free article.

3

Combined treatment with the checkpoint abrogator UCN-01 and MEK1/2 inhibitors potently induces apoptosis in drug-sensitive and -resistant myeloma cells through an IL-6-independent mechanism.

Dai Y, Landowski TH, Rosen ST, Dent P, Grant S. Dai Y, et al. Among authors: dent p. Blood. 2002 Nov 1;100(9):3333-43. doi: 10.1182/blood-2002-03-0940. Blood. 2002. PMID: 12384435 Free article.

4

Inhibitors of MEK1/2 interact with UCN-01 to induce apoptosis and reduce colony formation in mammary and prostate carcinoma cells.

McKinstry R, Qiao L, Yacoub A, Dai Y, Decker R, Holt S, Hagan MP, Grant S, Dent P. McKinstry R, et al. Among authors: dent p. Cancer Biol Ther. 2002 May-Jun;1(3):243-53. doi: 10.4161/cbt.75. Cancer Biol Ther. 2002. PMID: 12432271 Free article.

5

Coadministration of UCN-01 with MEK1/2 inhibitors potently induces apoptosis in BCR/ABL+ leukemia cells sensitive and resistant to ST1571.

Yu C, Dai Y, Dent P, Grant S. Yu C, et al. Among authors: dent p. Cancer Biol Ther. 2002 Nov-Dec;1(6):674-82. doi: 10.4161/cbt.319. Cancer Biol Ther. 2002. PMID: 12642693 Free article.

6

The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process.

Yu C, Rahmani M, Dai Y, Conrad D, Krystal G, Dent P, Grant S. Yu C, et al. Among authors: dent p. Cancer Res. 2003 Apr 15;63(8):1822-33. Cancer Res. 2003. PMID: 12702569

7

MDA-7 (interleukin-24) inhibits the proliferation of renal carcinoma cells and interacts with free radicals to promote cell death and loss of reproductive capacity.

Yacoub A, Mitchell C, Brannon J, Rosenberg E, Qiao L, McKinstry R, Linehan WM, Su ZS, Sarkar D, Lebedeva IV, Valerie K, Gopalkrishnan RV, Grant S, Fisher PB, Dent P. Yacoub A, et al. Among authors: dent p. Mol Cancer Ther. 2003 Jul;2(7):623-32. Mol Cancer Ther. 2003. PMID: 12883035

8

Interruption of the NF-kappaB pathway by Bay 11-7082 promotes UCN-01-mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells.

Dai Y, Pei XY, Rahmani M, Conrad DH, Dent P, Grant S. Dai Y, et al. Among authors: dent p. Blood. 2004 Apr 1;103(7):2761-70. doi: 10.1182/blood-2003-09-3037. Epub 2003 Nov 26. Blood. 2004. PMID: 14645003 Free article.

9

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) promotes mitochondrial dysfunction and apoptosis induced by 7-hydroxystaurosporine and mitogen-activated protein kinase kinase inhibitors in human leukemia cells that ectopically express Bcl-2 and Bcl-xL.

Dai Y, Dent P, Grant S. Dai Y, et al. Among authors: dent p. Mol Pharmacol. 2003 Dec;64(6):1402-9. doi: 10.1124/mol.64.6.1402. Mol Pharmacol. 2003. PMID: 14645670

10

Sequence dependent exposure of mammary carcinoma cells to Taxotere and the MEK1/2 inhibitor U0126 causes enhanced cell killing in vitro.

Yacoub A, Han SI, Caron R, Gilfor D, Mooberry S, Grant S, Dent P. Yacoub A, et al. Among authors: dent p. Cancer Biol Ther. 2003 Nov-Dec;2(6):670-6. Cancer Biol Ther. 2003. PMID: 14688474

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