Becker TC - Search Results

1

Chronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolism.

Ronnebaum SM, Joseph JW, Ilkayeva O, Burgess SC, Lu D, Becker TC, Sherry AD, Newgard CB. Ronnebaum SM, et al. Among authors: becker tc. J Biol Chem. 2008 May 23;283(21):14248-56. doi: 10.1074/jbc.M800119200. Epub 2008 Apr 1. J Biol Chem. 2008. PMID: 18381287 Free PMC article.

2

Adenovirus-mediated overexpression of liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in gluconeogenic rat hepatoma cells. Paradoxical effect on Fru-2,6-P2 levels.

Argaud D, Lange AJ, Becker TC, Okar DA, el-Maghrabi MR, Newgard CB, Pilkis SJ. Argaud D, et al. Among authors: becker tc. J Biol Chem. 1995 Oct 13;270(41):24229-36. doi: 10.1074/jbc.270.41.24229. J Biol Chem. 1995. PMID: 7592629 Free article.

3

Overexpression of hexokinase I in isolated islets of Langerhans via recombinant adenovirus. Enhancement of glucose metabolism and insulin secretion at basal but not stimulatory glucose levels.

Becker TC, BeltrandelRio H, Noel RJ, Johnson JH, Newgard CB. Becker TC, et al. J Biol Chem. 1994 Aug 19;269(33):21234-8. J Biol Chem. 1994. PMID: 8063745 Free article.

4

GLUT-2 gene transfer into insulinoma cells confers both low and high affinity glucose-stimulated insulin release. Relationship to glucokinase activity.

Ferber S, BeltrandelRio H, Johnson JH, Noel RJ, Cassidy LE, Clark S, Becker TC, Hughes SD, Newgard CB. Ferber S, et al. Among authors: becker tc. J Biol Chem. 1994 Apr 15;269(15):11523-9. J Biol Chem. 1994. PMID: 8157682 Free article.

5

Differential effects of overexpressed glucokinase and hexokinase I in isolated islets. Evidence for functional segregation of the high and low Km enzymes.

Becker TC, Noel RJ, Johnson JH, Lynch RM, Hirose H, Tokuyama Y, Bell GI, Newgard CB. Becker TC, et al. J Biol Chem. 1996 Jan 5;271(1):390-4. doi: 10.1074/jbc.271.1.390. J Biol Chem. 1996. PMID: 8550593 Free article.

6

Regulation of overexpressed hexokinases in liver and islet cells.

Newgard CB, Becker TC, Berman HK, O'Doherty RM. Newgard CB, et al. Among authors: becker tc. Biochem Soc Trans. 1997 Feb;25(1):118-22. doi: 10.1042/bst0250118. Biochem Soc Trans. 1997. PMID: 9056855 Review. No abstract available.

7

An adenovirus vector for efficient RNA interference-mediated suppression of target genes in insulinoma cells and pancreatic islets of langerhans.

Bain JR, Schisler JC, Takeuchi K, Newgard CB, Becker TC. Bain JR, et al. Among authors: becker tc. Diabetes. 2004 Sep;53(9):2190-4. doi: 10.2337/diabetes.53.9.2190. Diabetes. 2004. PMID: 15331526

8

Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes.

Iype T, Francis J, Garmey JC, Schisler JC, Nesher R, Weir GC, Becker TC, Newgard CB, Griffen SC, Mirmira RG. Iype T, et al. Among authors: becker tc. J Biol Chem. 2005 Apr 29;280(17):16798-807. doi: 10.1074/jbc.M414381200. Epub 2005 Mar 2. J Biol Chem. 2005. PMID: 15743769 Free article.

9

The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells.

Schisler JC, Jensen PB, Taylor DG, Becker TC, Knop FK, Takekawa S, German M, Weir GC, Lu D, Mirmira RG, Newgard CB. Schisler JC, et al. Among authors: becker tc. Proc Natl Acad Sci U S A. 2005 May 17;102(20):7297-302. doi: 10.1073/pnas.0502168102. Epub 2005 May 9. Proc Natl Acad Sci U S A. 2005. PMID: 15883383 Free PMC article.

10

Compensatory responses to pyruvate carboxylase suppression in islet beta-cells. Preservation of glucose-stimulated insulin secretion.

Jensen MV, Joseph JW, Ilkayeva O, Burgess S, Lu D, Ronnebaum SM, Odegaard M, Becker TC, Sherry AD, Newgard CB. Jensen MV, et al. Among authors: becker tc. J Biol Chem. 2006 Aug 4;281(31):22342-22351. doi: 10.1074/jbc.M604350200. Epub 2006 Jun 1. J Biol Chem. 2006. PMID: 16740637 Free article.

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