Evans DC - Search Results

1

A generic method to detect electrophilic intermediates using isotopic pattern triggered data-dependent high-resolution accurate mass spectrometry.

Lim HK, Chen J, Cook K, Sensenhauser C, Silva J, Evans DC. Lim HK, et al. Among authors: evans dc. Rapid Commun Mass Spectrom. 2008 Apr;22(8):1295-311. doi: 10.1002/rcm.3504. Rapid Commun Mass Spectrom. 2008. PMID: 18383206

2

Overcoming the genotoxicity of a pyrrolidine substituted arylindenopyrimidine as a potent dual adenosine A(2A)/A(1) antagonist by minimizing bioactivation to an iminium ion reactive intermediate.

Lim HK, Chen J, Sensenhauser C, Cook K, Preston R, Thomas T, Shook B, Jackson PF, Rassnick S, Rhodes K, Gopaul V, Salter R, Silva J, Evans DC. Lim HK, et al. Among authors: evans dc. Chem Res Toxicol. 2011 Jul 18;24(7):1012-30. doi: 10.1021/tx1004437. Epub 2011 Jun 28. Chem Res Toxicol. 2011. PMID: 21667953

3

Free radical metabolism of raloxifene in human liver microsomes.

Lim HK, Yang M, Lam W, Xu F, Chen J, Xu Y, Shetty HU, Yang K, Silva J, Evans DC. Lim HK, et al. Among authors: evans dc. Xenobiotica. 2012 Aug;42(8):737-47. doi: 10.3109/00498254.2012.662306. Xenobiotica. 2012. PMID: 22375838

4

LC-ESI-MS/MS quantification of 4β-hydroxycholesterol and cholesterol in plasma samples of limited volume.

Xu Y, Yuan Y, Smith L, Edom R, Weng N, Mamidi R, Silva J, Evans DC, Lim HK. Xu Y, et al. Among authors: evans dc. J Pharm Biomed Anal. 2013 Nov;85:145-54. doi: 10.1016/j.jpba.2013.07.016. Epub 2013 Jul 25. J Pharm Biomed Anal. 2013. PMID: 23948760

5

A nonradioactive approach to investigate the metabolism of therapeutic peptides by tagging with 127i and using inductively-coupled plasma mass spectrometry analysis.

Lim HK, Cao Y, Qiu X, Silva J, Evans DC. Lim HK, et al. Among authors: evans dc. Drug Metab Dispos. 2015 Jan;43(1):17-26. doi: 10.1124/dmd.114.059774. Epub 2014 Oct 14. Drug Metab Dispos. 2015. PMID: 25315343

6

Trace level quantification of deuterated 17beta-estradiol and estrone in ovariectomized mouse plasma and brain using liquid chromatography/tandem mass spectrometry following dansylation reaction.

Xia YQ, Chang SW, Patel S, Bakhtiar R, Karanam B, Evans DC. Xia YQ, et al. Among authors: evans dc. Rapid Commun Mass Spectrom. 2004;18(14):1621-8. doi: 10.1002/rcm.1530. Rapid Commun Mass Spectrom. 2004. PMID: 15282788

7

In vitro and physiologically-based pharmacokinetic based assessment of drug-drug interaction potential of canagliflozin.

Mamidi RNVS, Dallas S, Sensenhauser C, Lim HK, Scheers E, Verboven P, Cuyckens F, Leclercq L, Evans DC, Kelley MF, Johnson MD, Snoeys J. Mamidi RNVS, et al. Among authors: evans dc. Br J Clin Pharmacol. 2017 May;83(5):1082-1096. doi: 10.1111/bcp.13186. Epub 2016 Dec 20. Br J Clin Pharmacol. 2017. PMID: 27862160 Free PMC article.

8

Metabolism and excretion of canagliflozin in mice, rats, dogs, and humans.

Mamidi RN, Cuyckens F, Chen J, Scheers E, Kalamaridis D, Lin R, Silva J, Sha S, Evans DC, Kelley MF, Devineni D, Johnson MD, Lim HK. Mamidi RN, et al. Among authors: evans dc. Drug Metab Dispos. 2014 May;42(5):903-16. doi: 10.1124/dmd.113.056440. Epub 2014 Feb 25. Drug Metab Dispos. 2014. PMID: 24568888 Clinical Trial.

9

Gut-Restricted Selective Cyclooxygenase-2 (COX-2) Inhibitors for Chemoprevention of Colorectal Cancer.

Zhang Z, Ghosh A, Connolly PJ, King P, Wilde T, Wang J, Dong Y, Li X, Liao D, Chen H, Tian G, Suarez J, Bonnette WG, Pande V, Diloreto KA, Shi Y, Patel S, Pietrak B, Szewczuk L, Sensenhauser C, Dallas S, Edwards JP, Bachman KE, Evans DC. Zhang Z, et al. Among authors: evans dc. J Med Chem. 2021 Aug 12;64(15):11570-11596. doi: 10.1021/acs.jmedchem.1c00890. Epub 2021 Jul 19. J Med Chem. 2021. PMID: 34279934

10

Addressing the metabolic activation potential of new leads in drug discovery: a case study using ion trap mass spectrometry and tritium labeling techniques.

Samuel K, Yin W, Stearns RA, Tang YS, Chaudhary AG, Jewell JP, Lanza T Jr, Lin LS, Hagmann WK, Evans DC, Kumar S. Samuel K, et al. Among authors: evans dc. J Mass Spectrom. 2003 Feb;38(2):211-21. doi: 10.1002/jms.434. J Mass Spectrom. 2003. PMID: 12577288

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