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Therapeutic benefit derived from RNAi-mediated ablation of IMPDH1 transcripts in a murine model of autosomal dominant retinitis pigmentosa (RP10).
Tam LC, Kiang AS, Kennan A, Kenna PF, Chadderton N, Ader M, Palfi A, Aherne A, Ayuso C, Campbell M, Reynolds A, McKee A, Humphries MM, Farrar GJ, Humphries P. Tam LC, et al. Among authors: kiang as. Hum Mol Genet. 2008 Jul 15;17(14):2084-100. doi: 10.1093/hmg/ddn107. Epub 2008 Apr 1. Hum Mol Genet. 2008. PMID: 18385099
A dominant mutation in RPE65 identified by whole-exome sequencing causes retinitis pigmentosa with choroidal involvement.
Bowne SJ, Humphries MM, Sullivan LS, Kenna PF, Tam LC, Kiang AS, Campbell M, Weinstock GM, Koboldt DC, Ding L, Fulton RS, Sodergren EJ, Allman D, Millington-Ward S, Palfi A, McKee A, Blanton SH, Slifer S, Konidari I, Farrar GJ, Daiger SP, Humphries P. Bowne SJ, et al. Among authors: kiang as. Eur J Hum Genet. 2011 Oct;19(10):1074-81. doi: 10.1038/ejhg.2011.86. Epub 2011 Jun 8. Eur J Hum Genet. 2011. PMID: 21654732 Free PMC article.
RNAi of COL1A1 in mesenchymal progenitor cells.
Millington-Ward S, McMahon HP, Allen D, Tuohy G, Kiang AS, Palfi A, Kenna PF, Humphries P, Farrar GJ. Millington-Ward S, et al. Among authors: kiang as. Eur J Hum Genet. 2004 Oct;12(10):864-6. doi: 10.1038/sj.ejhg.5201230. Eur J Hum Genet. 2004. PMID: 15241481
RNA interference-mediated suppression and replacement of human rhodopsin in vivo.
O'Reilly M, Palfi A, Chadderton N, Millington-Ward S, Ader M, Cronin T, Tuohy T, Auricchio A, Hildinger M, Tivnan A, McNally N, Humphries MM, Kiang AS, Humphries P, Kenna PF, Farrar GJ. O'Reilly M, et al. Among authors: kiang as. Am J Hum Genet. 2007 Jul;81(1):127-35. doi: 10.1086/519025. Epub 2007 May 23. Am J Hum Genet. 2007. PMID: 17564969 Free PMC article.
An experimental platform for systemic drug delivery to the retina.
Campbell M, Nguyen AT, Kiang AS, Tam LC, Gobbo OL, Kerskens C, Ni Dhubhghaill S, Humphries MM, Farrar GJ, Kenna PF, Humphries P. Campbell M, et al. Among authors: kiang as. Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17817-22. doi: 10.1073/pnas.0908561106. Epub 2009 Oct 12. Proc Natl Acad Sci U S A. 2009. PMID: 19822744 Free PMC article.
40 results