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Therapeutic benefit derived from RNAi-mediated ablation of IMPDH1 transcripts in a murine model of autosomal dominant retinitis pigmentosa (RP10).
Tam LC, Kiang AS, Kennan A, Kenna PF, Chadderton N, Ader M, Palfi A, Aherne A, Ayuso C, Campbell M, Reynolds A, McKee A, Humphries MM, Farrar GJ, Humphries P. Tam LC, et al. Among authors: palfi a. Hum Mol Genet. 2008 Jul 15;17(14):2084-100. doi: 10.1093/hmg/ddn107. Epub 2008 Apr 1. Hum Mol Genet. 2008. PMID: 18385099
Strategems in vitro for gene therapies directed to dominant mutations.
Millington-Ward S, O'Neill B, Tuohy G, Al-Jandal N, Kiang AS, Kenna PF, Palfi A, Hayden P, Mansergh F, Kennan A, Humphries P, Farrar GJ. Millington-Ward S, et al. Among authors: palfi a. Hum Mol Genet. 1997 Sep;6(9):1415-26. doi: 10.1093/hmg/6.9.1415. Hum Mol Genet. 1997. PMID: 9285777
Identification of an IMPDH1 mutation in autosomal dominant retinitis pigmentosa (RP10) revealed following comparative microarray analysis of transcripts derived from retinas of wild-type and Rho(-/-) mice.
Kennan A, Aherne A, Palfi A, Humphries M, McKee A, Stitt A, Simpson DA, Demtroder K, Orntoft T, Ayuso C, Kenna PF, Farrar GJ, Humphries P. Kennan A, et al. Among authors: palfi a. Hum Mol Genet. 2002 Mar 1;11(5):547-57. doi: 10.1093/hmg/11.5.547. Hum Mol Genet. 2002. PMID: 11875049
RNAi of COL1A1 in mesenchymal progenitor cells.
Millington-Ward S, McMahon HP, Allen D, Tuohy G, Kiang AS, Palfi A, Kenna PF, Humphries P, Farrar GJ. Millington-Ward S, et al. Among authors: palfi a. Eur J Hum Genet. 2004 Oct;12(10):864-6. doi: 10.1038/sj.ejhg.5201230. Eur J Hum Genet. 2004. PMID: 15241481
Development of strategies for conditional RNA interference.
Allen D, Kenna PF, Palfi A, McMahon HP, Millington-Ward S, O'Reilly M, Humphries P, Farrar GJ. Allen D, et al. Among authors: palfi a. J Gene Med. 2007 Apr;9(4):287-98. doi: 10.1002/jgm.1018. J Gene Med. 2007. PMID: 17397092
RNA interference-mediated suppression and replacement of human rhodopsin in vivo.
O'Reilly M, Palfi A, Chadderton N, Millington-Ward S, Ader M, Cronin T, Tuohy T, Auricchio A, Hildinger M, Tivnan A, McNally N, Humphries MM, Kiang AS, Humphries P, Kenna PF, Farrar GJ. O'Reilly M, et al. Among authors: palfi a. Am J Hum Genet. 2007 Jul;81(1):127-35. doi: 10.1086/519025. Epub 2007 May 23. Am J Hum Genet. 2007. PMID: 17564969 Free PMC article.
A transgenic mouse model for gene therapy of rhodopsin-linked Retinitis Pigmentosa.
O'Reilly M, Millington-Ward S, Palfi A, Chadderton N, Cronin T, McNally N, Humphries MM, Humphries P, Kenna PF, Farrar GJ. O'Reilly M, et al. Among authors: palfi a. Vision Res. 2008 Feb;48(3):386-91. doi: 10.1016/j.visres.2007.08.014. Epub 2007 Oct 24. Vision Res. 2008. PMID: 17920651 Free article.
84 results