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Rational design of novel, potent piperazinone and imidazolidinone BACE1 inhibitors.
Cumming JN, Le TX, Babu S, Carroll C, Chen X, Favreau L, Gaspari P, Guo T, Hobbs DW, Huang Y, Iserloh U, Kennedy ME, Kuvelkar R, Li G, Lowrie J, McHugh NA, Ozgur L, Pan J, Parker EM, Saionz K, Stamford AW, Strickland C, Tadesse D, Voigt J, Wang L, Wu Y, Zhang L, Zhang Q. Cumming JN, et al. Among authors: zhang l, zhang q. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3236-41. doi: 10.1016/j.bmcl.2008.04.050. Epub 2008 Apr 25. Bioorg Med Chem Lett. 2008. PMID: 18468890
Discovery of an orally efficaceous 4-phenoxypyrrolidine-based BACE-1 inhibitor.
Iserloh U, Pan J, Stamford AW, Kennedy ME, Zhang Q, Zhang L, Parker EM, McHugh NA, Favreau L, Strickland C, Voigt J. Iserloh U, et al. Among authors: zhang l, zhang q. Bioorg Med Chem Lett. 2008 Jan 1;18(1):418-22. doi: 10.1016/j.bmcl.2007.10.053. Epub 2007 Oct 18. Bioorg Med Chem Lett. 2008. PMID: 17980584
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