Figueroa H - Search Results

1

A transgenic rat that develops Alzheimer's disease-like amyloid pathology, deficits in synaptic plasticity and cognitive impairment.

Liu L, Orozco IJ, Planel E, Wen Y, Bretteville A, Krishnamurthy P, Wang L, Herman M, Figueroa H, Yu WH, Arancio O, Duff K. Liu L, et al. Among authors: figueroa h. Neurobiol Dis. 2008 Jul;31(1):46-57. doi: 10.1016/j.nbd.2008.03.005. Epub 2008 Apr 7. Neurobiol Dis. 2008. PMID: 18504134 Free PMC article.

2

Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing.

Wen Y, Planel E, Herman M, Figueroa HY, Wang L, Liu L, Lau LF, Yu WH, Duff KE. Wen Y, et al. J Neurosci. 2008 Mar 5;28(10):2624-32. doi: 10.1523/JNEUROSCI.5245-07.2008. J Neurosci. 2008. PMID: 18322105 Free PMC article.

3

Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing.

Wen Y, Yu WH, Maloney B, Bailey J, Ma J, Marié I, Maurin T, Wang L, Figueroa H, Herman M, Krishnamurthy P, Liu L, Planel E, Lau LF, Lahiri DK, Duff K. Wen Y, et al. Among authors: figueroa h. Neuron. 2008 Mar 13;57(5):680-90. doi: 10.1016/j.neuron.2008.02.024. Neuron. 2008. PMID: 18341989 Free PMC article.

4

Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo.

Planel E, Krishnamurthy P, Miyasaka T, Liu L, Herman M, Kumar A, Bretteville A, Figueroa HY, Yu WH, Whittington RA, Davies P, Takashima A, Nixon RA, Duff KE. Planel E, et al. J Neurosci. 2008 Nov 26;28(48):12798-807. doi: 10.1523/JNEUROSCI.4101-08.2008. J Neurosci. 2008. PMID: 19036972 Free PMC article.

5

Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein.

Yu WH, Dorado B, Figueroa HY, Wang L, Planel E, Cookson MR, Clark LN, Duff KE. Yu WH, et al. Am J Pathol. 2009 Aug;175(2):736-47. doi: 10.2353/ajpath.2009.080928. Epub 2009 Jul 23. Am J Pathol. 2009. PMID: 19628769 Free PMC article.

6

Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons.

Wu JW, Herman M, Liu L, Simoes S, Acker CM, Figueroa H, Steinberg JI, Margittai M, Kayed R, Zurzolo C, Di Paolo G, Duff KE. Wu JW, et al. Among authors: figueroa h. J Biol Chem. 2013 Jan 18;288(3):1856-70. doi: 10.1074/jbc.M112.394528. Epub 2012 Nov 27. J Biol Chem. 2013. PMID: 23188818 Free PMC article.

7

3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau Accumulation Associated with Neuronal Loss and Recognition Memory Deficit in Aged Tau Transgenic Mice.

Fu H, Hussaini SA, Wegmann S, Profaci C, Daniels JD, Herman M, Emrani S, Figueroa HY, Hyman BT, Davies P, Duff KE. Fu H, et al. Among authors: figueroa hy. PLoS One. 2016 Jul 28;11(7):e0159463. doi: 10.1371/journal.pone.0159463. eCollection 2016. PLoS One. 2016. PMID: 27466814 Free PMC article.

8

Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer's Disease.

Fu H, Rodriguez GA, Herman M, Emrani S, Nahmani E, Barrett G, Figueroa HY, Goldberg E, Hussaini SA, Duff KE. Fu H, et al. Among authors: figueroa hy. Neuron. 2017 Feb 8;93(3):533-541.e5. doi: 10.1016/j.neuron.2016.12.023. Epub 2017 Jan 19. Neuron. 2017. PMID: 28111080 Free PMC article.

9

Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer's disease-like pathology.

Nuriel T, Angulo SL, Khan U, Ashok A, Chen Q, Figueroa HY, Emrani S, Liu L, Herman M, Barrett G, Savage V, Buitrago L, Cepeda-Prado E, Fung C, Goldberg E, Gross SS, Hussaini SA, Moreno H, Small SA, Duff KE. Nuriel T, et al. Among authors: figueroa hy. Nat Commun. 2017 Nov 13;8(1):1464. doi: 10.1038/s41467-017-01444-0. Nat Commun. 2017. PMID: 29133888 Free PMC article.

10

The Endosomal-Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo.

Nuriel T, Peng KY, Ashok A, Dillman AA, Figueroa HY, Apuzzo J, Ambat J, Levy E, Cookson MR, Mathews PM, Duff KE. Nuriel T, et al. Front Neurosci. 2017 Dec 12;11:702. doi: 10.3389/fnins.2017.00702. eCollection 2017. Front Neurosci. 2017. PMID: 29311783 Free PMC article.

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