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Severe acute respiratory syndrome coronavirus 3C-like proteinase N terminus is indispensable for proteolytic activity but not for enzyme dimerization. Biochemical and thermodynamic investigation in conjunction with molecular dynamics simulations.
Chen S, Chen L, Tan J, Chen J, Du L, Sun T, Shen J, Chen K, Jiang H, Shen X. Chen S, et al. Among authors: chen j, chen k, chen l. J Biol Chem. 2005 Jan 7;280(1):164-73. doi: 10.1074/jbc.M408211200. Epub 2004 Oct 26. J Biol Chem. 2005. PMID: 15507456 Free PMC article.
Mutation of Gly-11 on the dimer interface results in the complete crystallographic dimer dissociation of severe acute respiratory syndrome coronavirus 3C-like protease: crystal structure with molecular dynamics simulations.
Chen S, Hu T, Zhang J, Chen J, Chen K, Ding J, Jiang H, Shen X. Chen S, et al. Among authors: chen j, chen k. J Biol Chem. 2008 Jan 4;283(1):554-564. doi: 10.1074/jbc.M705240200. Epub 2007 Oct 31. J Biol Chem. 2008. PMID: 17977841 Free PMC article.
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