Newton AC - Search Results

1

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C.

Facchinetti V, Ouyang W, Wei H, Soto N, Lazorchak A, Gould C, Lowry C, Newton AC, Mao Y, Miao RQ, Sessa WC, Qin J, Zhang P, Su B, Jacinto E. Facchinetti V, et al. Among authors: newton ac. EMBO J. 2008 Jul 23;27(14):1932-43. doi: 10.1038/emboj.2008.120. Epub 2008 Jun 19. EMBO J. 2008. PMID: 18566586 Free PMC article.

2

Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase.

Chen D, Gould C, Garza R, Gao T, Hampton RY, Newton AC. Chen D, et al. Among authors: newton ac. J Biol Chem. 2007 Nov 16;282(46):33776-33787. doi: 10.1074/jbc.M703320200. Epub 2007 Sep 24. J Biol Chem. 2007. PMID: 17893151 Free article.

3

The life and death of protein kinase C.

Gould CM, Newton AC. Gould CM, et al. Among authors: newton ac. Curr Drug Targets. 2008 Aug;9(8):614-25. doi: 10.2174/138945008785132411. Curr Drug Targets. 2008. PMID: 18691009 Free PMC article. Review.

4

The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail.

Gould CM, Kannan N, Taylor SS, Newton AC. Gould CM, et al. Among authors: newton ac. J Biol Chem. 2009 Feb 20;284(8):4921-35. doi: 10.1074/jbc.M808436200. Epub 2008 Dec 17. J Biol Chem. 2009. PMID: 19091746 Free PMC article.

5

Interaction with AKAP79 modifies the cellular pharmacology of PKC.

Hoshi N, Langeberg LK, Gould CM, Newton AC, Scott JD. Hoshi N, et al. Among authors: newton ac. Mol Cell. 2010 Feb 26;37(4):541-50. doi: 10.1016/j.molcel.2010.01.014. Mol Cell. 2010. PMID: 20188672 Free PMC article.

6

Active site inhibitors protect protein kinase C from dephosphorylation and stabilize its mature form.

Gould CM, Antal CE, Reyes G, Kunkel MT, Adams RA, Ziyar A, Riveros T, Newton AC. Gould CM, et al. Among authors: newton ac. J Biol Chem. 2011 Aug 19;286(33):28922-28930. doi: 10.1074/jbc.M111.272526. Epub 2011 Jun 29. J Biol Chem. 2011. PMID: 21715334 Free PMC article.

7

Protein kinase Cζ exhibits constitutive phosphorylation and phosphatidylinositol-3,4,5-triphosphate-independent regulation.

Tobias IS, Kaulich M, Kim PK, Simon N, Jacinto E, Dowdy SF, King CC, Newton AC. Tobias IS, et al. Among authors: newton ac. Biochem J. 2016 Feb 15;473(4):509-23. doi: 10.1042/BJ20151013. Epub 2015 Dec 3. Biochem J. 2016. PMID: 26635352 Free PMC article.

8

mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif.

Baffi TR, Lordén G, Wozniak JM, Feichtner A, Yeung W, Kornev AP, King CC, Del Rio JC, Limaye AJ, Bogomolovas J, Gould CM, Chen J, Kennedy EJ, Kannan N, Gonzalez DJ, Stefan E, Taylor SS, Newton AC. Baffi TR, et al. Among authors: newton ac. Sci Signal. 2021 Apr 13;14(678):eabe4509. doi: 10.1126/scisignal.abe4509. Sci Signal. 2021. PMID: 33850054 Free PMC article.

9

PHLiPPing the switch on Akt and protein kinase C signaling.

Brognard J, Newton AC. Brognard J, et al. Among authors: newton ac. Trends Endocrinol Metab. 2008 Aug;19(6):223-30. doi: 10.1016/j.tem.2008.04.001. Epub 2008 May 27. Trends Endocrinol Metab. 2008. PMID: 18511290 Free PMC article. Review.

10

Protein Kinase C Quality Control by Phosphatase PHLPP1 Unveils Loss-of-Function Mechanism in Cancer.

Baffi TR, Van AN, Zhao W, Mills GB, Newton AC. Baffi TR, et al. Among authors: newton ac. Mol Cell. 2019 Apr 18;74(2):378-392.e5. doi: 10.1016/j.molcel.2019.02.018. Epub 2019 Mar 20. Mol Cell. 2019. PMID: 30904392 Free PMC article.

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